Insights on the Study of NMN Combination Therapy Improve Health Tissue

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- Updated by Jody Mullis
Medically reviewed by Dr Sidra Samad

Insights on the Study of NMN Combination Therapy Improve Health Tissue


A study was undertaken to explore how supplementing Nicotinamide Mononucleotide (NMN), a crucial element in aging and diseases, could be boosted when combined with other nutrients. The research, published in the Pharmacol Res Perspect journal in August 2022, delved into whether adding natural products like resveratrol or ginsenoside among others to NMN could enhance its levels in specific tissues. The study can be found here.

NMN serves as a necessary precursor to Nicotinamide Adenine Dinucleotide (NAD+), an important co-factor that participates in a range of biological processes, including the production of energy in cells. A decrease in NAD+ is a noteworthy factor in aging and is linked to various diseases.

NMN was orally administered to mice in the study, combined either with resveratrol or with ginsenoside Rh2 & Rg3. The findings demonstrated that the combination of NMN and resveratrol substantially increased the concentrations of NAD+ in heart and muscle tissues, compared to NMN alone, by approximately 1.6 and 1.7 times respectively. NMN coupled with ginsenoside Rh2 & Rg3 significantly improved NAD+ levels in lung tissue by about twice as much as administering NMN alone.

These results provide exciting new avenues in developing treatment solutions for diseases caused by decreased NAD+ levels, especially cardiopulmonary illnesses. The use of resveratrol or ginsenoside to enhance NMN action shows potential in aiding the battle against aging and related diseases.