Pure Calcium Alpha-Ketoglutarate - CA-AKG Supplement

Amplifying cellular health, Our 99% pure Ca-AKG supports over 200 genes that are critical for reducing oxidative stress.
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99% Purity
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  • Over 99% pure
  • Independently lab tested
  • Gluten-free, vegan and allergy friendly

 

lab certified

 

What Is Calcium Alpha-Ketoglutarate

Calcium Alpha-ketoglutarate (Ca-AKG) is a compound created naturally in the body but diminishes as we age. A 2008 review article on the subject noted AKG blood levels can drop by a factor of ten between the ages of 40 and 80. 

A multi-year study at the Buck Institute for Research on aging has indicated that in animal models, Ca-AKG can promote longer, healthier lives associated with a decrease in levels of inflammatory cytokines. Furthermore, the reduction in frailty was observed to be more dramatic than the increase in lifespan, suggesting that Ca-AKG compresses the period of later-life suffering of disease. The same study found that Ca-AKG was found to modulate the pathways that are associated with healthy aging, including DNA de-methylation, and potentially decrease biological age as defined by the science of biological clocks. The study focused on 31 frailty markers and tested for a multitude of biomarkers related to aging and inflammation. The researchers found that mice in the test group experienced a 12% increase in lifespan, and perhaps even more significantly, a 46% reduction in frailty, and 41% increase in healthspan.

Dosage and Guidance

Take with or without food. For those who prefer powder, capsules can be opened and mixed in a meal or drink.

 

Suggested Daily Dosage:

2 capsules per day.

Upper Dosage (Depending upon the age and other factors):

4 capsules per day.

Referencing and Further Readings:

For the individuals who are interested in more details and knowledge about Calcium Alpha-ketoglutarate (Ca-AKG) and Alpha ketoglutarate (AKG), here is a list of references to help you with your study. Moreover, you can watch this video by Lecturio Medical where the professional is discusses the Calcium Alpha ketoglutarate (Ca-AKG) family and Glutamine syntheses. 

Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1.

Hajishengallis, G., 2010. Too old to fight? Aging and its toll on innate immunity. Molecular oral microbiology, 25(1), pp.25-37.

Xiao, D., Zeng, L., Yao, K., Kong, X., Wu, G. and Yin, Y., 2016. The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications. Amino acids, 48(9), pp.2067-2080.

Shahmirzadi, A.A., Edgar, D., Liao, C.Y., Hsu, Y.M., Lucanic, M., Shahmirzadi, A.A., Wiley, C.D., Gan, G., Kim, D.E., Kasler, H.G. and Kuehnemann, C., 2020. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metabolism, 32(3), pp.447-456.

Kaczka, P., Batra, A., Kubicka, K., Maciejczyk, M., Jastrząb, R., Kopera, E., Bira, J. and Zając, T., 2020. Effects of Co-Ingestion of AAKG and HMB on Jumping Performance in Young Track and Field Athletes.

Liu, S., He, L. and Yao, K., 2018. The antioxidative function of alpha-ketoglutarate and its applications. BioMed research international, 2018.

Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1.

Prandini, A., Morlacchini, M., Sigolo, S., Fiorentini, L. and Gallo, A., 2012. Anticatabolic activity of alpha-ketoglutaric acid in growing rats. Italian Journal of Animal Science, 11(3), p.e52.

Dulaney Jr, M.D., Brumley, M., Willis, J.T. and Hume, A.S., 1991. Protection against cyanide toxicity by oral alpha-ketoglutaric acid. Veterinary and human toxicology, 33(6), pp.571-575.

Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1. 

Disclaimers:

  • It is advised to use this product at your own discretion. Ca-AKG general consumption started in the 2000’s and long-term effects on humans are yet to be determined. 
  • Our products are supplements and should not be considered as an alternative for a varied diet.
  • Consult with your doctor before incorporating it into your daily routine.
  • Research on Ca-AKG is still ongoing and as more is discovered, the content on this website may get updated or changed altogether.

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