• Discover myricetin, a powerful plant-derived flavonoid known for its antioxidant properties. Learn about its benefits, recommended dosage, and potential side effects.

What is Myricetin? Benefits, Dosage, and Side Effects? Benefits, Dosage, and Side Effects

What is myricetin? This intriguing flavonoid, naturally found in various fruits, vegetables, and even tea has captured the attention of researchers for its extensive potential benefits. Myricetin has been shown to exhibit significant effects on cellular health and antioxidant levels, acting as a robust protector against free radicals and potentially even slowing down cellular ageing processes. Research have demonstrated that myricetin significantly impacts various body systems, including the cardiovascular and nervous systems. With the potential to support long-term wellness, myricetin also shows promise in reducing inflammation and enhancing resilience at the cellular level.

In this article, we'll delve into the remarkable properties of myricetin, exploring how myricetin suppresses the invasion of harmful cells, potentially protects against cancer, and modulates pathways in the body linked to chronic disease and ageing. Specific studies have found that myricetin in rat models successfully reduced inflammation and oxidative stress, while in human studies, myricetin in human t24 bladder cells showed an ability to inhibit cancer cell growth. 

Additionally, myricetin has exhibited the ability to influence other compounds beneficially, such as quercetin, to enhance overall health effects. These effects, along with activity by myricetin isolated from plant sources, illustrate its valuable place in longevity-focused supplements.

Here at Longevity Box, we’re proud to bring you products that are 99% pure, free from unnecessary additives, and backed by a 700-day purity guarantee. Our dedication to quality ensures that each supplement meets the highest standards of potency and safety.

Ready to explore Myricetin’s benefits in depth? In the sections that follow, we’ll unpack its mechanisms, health impacts, and how you might incorporate this impressive flavonoid into your wellness routine.

What is Myricetin?

Myricetin is a natural flavonoid, a type of polyphenolic compound, found in various plant-based foods such as berries, tea, red wine, and some leafy vegetables. Known for its vivid yellow pigment, it is part of the broader group of bioactive compounds known as flavonoids, which are recognised for their antioxidant, anti-inflammatory, and overall health-promoting properties. Structurally, myricetin is unique, possessing multiple hydroxyl groups that enable it to neutralise harmful free radicals effectively, thereby protecting cells from oxidative stress—a key factor in ageing and cellular degeneration.

The activity of myricetin has caught the attention of researchers worldwide. Studies have consistently shown that the compound may play a role in health maintenance by targeting processes that underlie chronic conditions. Its therapeutic appeal stems from its potential to protect cells, reduce inflammation, and possibly influence pathways associated with disease progression and cell ageing. This protective effect of myricetin underpins its appeal as a supplement in the quest for longevity and well-being.

Mechanism of Action of Myricetin: How Does Myricetin Work?

Antioxidant Activity

One of the primary actions of myricetin in the body is its powerful antioxidant activity. Free radicals are highly reactive molecules that can damage cells, DNA, and proteins, contributing to ageing and various diseases. Myricetin works by scavenging these free radicals and reducing oxidative stress. This action helps protect cells from damage that could otherwise accelerate ageing processes and increase the risk of chronic conditions.

Studies have also highlighted that myricetin may activate cellular pathways that naturally enhance the body’s own antioxidant defences, such as increasing the levels of glutathione, a vital cellular antioxidant. Research has reported that myricetin in human cells can exert protective effects, minimising oxidative harm and supporting cellular resilience.

Anti-inflammatory Activity of Myricetin

Inflammation is a necessary immune response, but chronic inflammation is linked to numerous health problems, including cardiovascular disease, arthritis, and neurodegeneration. Myricetin has been shown to inhibit enzymes associated with inflammation, such as cyclooxygenase (COX) and lipoxygenase, which play key roles in the inflammatory process. By reducing the production of pro-inflammatory molecules, myricetin may help to modulate the immune response and decrease chronic inflammation.

Interestingly, myricetin's action may also involve inhibiting the activation of certain pathways that contribute to inflammatory diseases. For instance, studies indicate that the compound suppresses the STAT1 protein—a known player in inflammatory signalling—suggesting a mechanism of action of myricetin that extends to both cellular health and inflammation control.

Potential Anti-cancer Mechanisms

Emerging research also indicates that myricetin may act as a natural inhibitor of tumour growth. It has demonstrated promising potential in laboratory studies to inhibit cell proliferation in various cancer cell lines, including those of the bladder and liver. Myricetin’s anticancer activity is thought to be partly due to its influence on cellular pathways that regulate cell growth and apoptosis (programmed cell death). This flavonoid has shown an ability to suppress angiogenesis (the formation of new blood vessels), which is crucial for cancerous tumours to grow and spread.

Furthermore, the compound has been shown to interfere with the DNA-binding ability of STAT1, a protein involved in tumour development. Such actions reinforce the potential of myricetin as part of a preventive approach to support cellular health and possibly reduce cancer risks.

Health Benefits: Potential of Myricetin

Cardiovascular Health

The cardiovascular benefits of myricetin are notable, particularly in its ability to reduce oxidative stress and inflammation in blood vessels. Oxidative stress can damage the endothelium, the inner lining of blood vessels, which plays a crucial role in vascular health. Research indicates that myricetin may improve blood flow by promoting endothelium-dependent relaxations and reducing contraction, thus supporting healthy blood pressure and circulation.

Key cardiovascular benefits of myricetin include:

• Improved vascular health
• Reduction in oxidative stress markers
• Anti-inflammatory effects on blood vessel walls
• Potential for lowering blood pressure

Neuroprotective Effects

Myricetin's impact on brain health is another area of promising research. Oxidative stress and inflammation are common factors in neurodegenerative diseases like Alzheimer’s and Parkinson’s. Myricetin, with its strong antioxidant and anti-inflammatory properties, has been shown to protect neurons (nerve cells) from damage in animal models. In one study, Myricetin has demonstrated neuroprotective properties by mitigating toxin-induced cytotoxicity in neural cells.

Benefits for brain health:

• Reduces oxidative damage in neural tissues
• Inhibits inflammation linked to neurodegenerative diseases
• Supports cognitive functions by protecting neurons

Anti-ageing and Cellular Longevity

Finally, myricetin’s effects on cellular health align well with longevity goals. By mitigating oxidative stress and reducing chronic inflammation, it supports the body’s natural defences against age-related cellular damage. The ability of myricetin to modulate pathways involved in inflammation and cancer growth suggests its possible role in promoting longevity by reducing risks of chronic diseases that commonly increase with age.

In essence, myricetin could be a valuable addition to a longevity-focused health regimen by offering protection against oxidative stress, inflammation, and cellular degeneration. With ongoing research revealing the extent of its benefits, myricetin holds promise as a multifaceted tool for enhancing health and potentially extending lifespan.

Potential Risks and Side Effects of Myricetin

Although myricetin is generally well-tolerated, some risks and side effects have been reported, especially at high doses commonly found in supplements. Studies have suggested that myricetin treatment could cause mild digestive discomfort, such as bloating or nausea, particularly when taken on an empty stomach. Additionally, high concentrations of myricetin may pose risks for certain individuals.

Possible Side Effects

• Gastrointestinal Issues: High doses, particularly when administration of myricetin exceeds dietary levels, have been linked to digestive discomfort, including nausea and diarrhoea. Such side effects have been observed in individuals treated with concentrated myricetin supplements.
• Allergic Reactions: Some people may experience allergic reactions to the flavonoid myricetin, such as rashes or itching. Although rare, those with a known sensitivity to plant flavonoids or polyphenols, including quercetin and myricetin, should approach supplements with caution.
• Potential Drug Interactions: Studies have demonstrated that the activity of myricetin in the body may affect certain medications, particularly those metabolised by the liver. The properties of myricetin as an enzyme modulator suggest that it could alter the effectiveness of certain drugs, including anticoagulants and anti-inflammatory medications.

Caution with High Doses

The mechanism of myricetin involves the modulation of cellular pathways, which can be beneficial for health but may cause side effects if taken in large amounts. Some research found that myricetin in high doses could lead to cell stress or toxicity, particularly in isolated studies. Myricetin is a potent flavonoid, so consulting a healthcare provider is recommended before starting high doses of myricetin treatment. This is especially advised for those with pre-existing health conditions who might experience different responses to treatment with myricetin.

Key Takeaways

• Gastrointestinal Discomfort: Potential for nausea or diarrhoea at high doses.
• Possible Allergic Reactions: Rare but can include skin irritation.
• Drug Interactions: Potential to interfere with liver-metabolised medications.

Dietary and Natural Sources of Myricetin

The effect of flavonoids like myricetin is best appreciated through a balanced diet. A wide range of foods offers this valuable compound naturally, providing a safe way to benefit from the flavonoid myricetin without the risks associated with high doses in supplement form. Studies have suggested that the combination of myricetin and other flavonoids found in foods may provide synergistic benefits.

Food Sources Rich in Myricetin

• Berries: Blueberries, cranberries, and blackberries are excellent sources. In laboratory studies, it was observed that myricetin was found to inhibit oxidative stress when present in these fruits.
• Tea: Both green and black teas contain polyphenolic myricetin, which, alongside other antioxidants, supports cardiovascular health.

• Red Wine: Contains myricetin and quercetin, both of which have anti-inflammatory properties. Moderate red wine consumption has been linked to a variety of health benefits due to the protective effect of myricetin and related compounds.
• Leafy Vegetables: Spinach and parsley also provide a concentration of myricetin along with other polyphenols.

Benefits of Obtaining Myricetin from Food

Dietary sources of myricetin provide a safe, steady intake that supports health naturally. A diet rich in myricetin and scutellarein as novel antioxidants offers a host of other nutrients that may improve cellular resilience and prevent oxidative stress. Additionally, the beneficial effect of myricetin can be amplified by the presence of other flavonoids, creating a more balanced antioxidant effect.

Myricetin Food Sources Quick List:

• Berries – Blueberries, blackberries, cranberries
• Tea – Green and black tea
• Red Wine – Contains myricetin glycoside compounds
• Leafy Greens – Spinach, kale, parsley

Supplements and Dosage of Myricetin

Myricetin, a powerful antioxidant with a wide range of health benefits, has gained attention for its potential in supporting cellular health, cardiovascular wellness, and immune function. Available in both capsule and powder forms, myricetin supplements offer a convenient way to incorporate this bioactive compound into daily routines, especially when dietary sources alone may fall short.

Studies on the activity of myricetin in human health suggest that this compound may play a role in cellular protection. Research highlights that myricetin exerts significant antioxidant effects, helping to neutralise free radicals and reduce oxidative stress. Daily doses between 100–500 mg are generally recommended for general health support, although higher doses may be explored under medical supervision for more targeted applications. For instance, ongoing studies are examining how myricetin inhibits proliferation of certain cell types, potentially supporting cellular resilience and longevity.

Enhancing Absorption and Efficacy of Myricetin

As a fat-soluble polyphenol, myricetin absorbs best when taken with meals containing healthy fats, which improves its bioavailability. Some studies indicate that myricetin suppresses invasion of harmful cells and attenuated inflammation, making it particularly promising in supporting long-term cellular health. To optimise these benefits, combining myricetin with other synergistic ingredients can amplify its effects.

Senolytic 8 from Longevity Box includes myricetin as part of a carefully curated blend, where it works alongside other active compounds like quercetin, NAC (N-Acetyl-Cysteine), and theaflavins. Together, these ingredients enhance the antioxidant and cellular defence benefits of myricetin. Within this formulation, myricetin inhibits proliferation of undesirable cells, while ingredients like NAC support detoxification and cellular repair. This synergy makes Senolytic 8 an ideal choice for individuals seeking a comprehensive supplement that combines multiple compounds with the potential anticancer activity of myricetin.

Summary of Myricetin Supplementation:

• Capsules: Controlled dosing, typically 100–500 mg daily
• Powder: Flexible for mixing into food or drink
• Absorption Tip: Take with a fat-containing meal for enhanced bioavailability
• Synergistic Formula: In Senolytic 8 from Longevity Box, the synergy of myricetin with other ingredients supports cellular vitality

The potential anticancer activity of myricetin, combined with its role in attenuating oxidative stress, makes it an ideal component in Senolytic 8. For those focused on cellular longevity and overall vitality, this formula provides balanced support through a unique combination of ingredients. As always, individuals should consider consulting a healthcare provider to personalise dosages and optimise their wellness regimen.

Conclusion

In considering myricetin’s potential, it’s clear that this novel flavonoid offers a range of intriguing health benefits. Scientific research has shown that myricetin protects cells from oxidative stress and damage, a process often induced by myricetin in studies to better understand its action. Known for its anti-inflammatory and antioxidant properties, myricetin also shows a promising capacity to reduce oxidative harm. For instance, myricetin significantly reduced markers of cell damage in various studies, suggesting its value in long-term cellular protection.

Interestingly, myricetin’s role in inflammation goes beyond mere surface-level action. Research shows that myricetin modulates key cellular pathways, such as those associated with STAT1, a pathway targeted by myricetin and delphinidin in cancer-related studies. It’s this ability to influence molecular functions that makes myricetin a candidate worth exploring for chronic inflammation and disease prevention. By influencing the STAT1 pathway, myricetin activates mechanisms that protect against certain inflammatory triggers, while also supporting cellular health.

Research using myricetin in mouse models has further illustrated its capacity to maintain balanced cellular functions. In certain studies, myricetin exhibited reduced rates of oxidative damage and inflammation, while other findings suggest that it attenuated toxic stress on cells. Evidence from myricetin in human T24 bladder cells even points to its ability to inhibit invasive cell activity, while its effects inhibited by myricetin across various cell lines show a consistent protective action.

While promising, the identification of myricetin as a therapeutic agent is still in the early stages, and its long-term effects need further exploration. For those considering myricetin concentration in supplement form, it’s essential to approach with care and consult healthcare providers. As studies continue to reveal activity by myricetin isolated from natural sources, it remains an exciting area of ongoing research.

If you’re interested in supporting your cellular health, or exploring options like myricetin for its long-term potential, we invite you to learn more by visiting our site at Longevity Box.

FAQ

What is myricetin and why is it unique?

Myricetin is a novel flavonoid found in fruits, tea, and red wine, known for its antioxidant and anti-inflammatory properties. Myricetin is also recognised for its potential to protect cells and reduce oxidative stress, making it a unique compound in health studies.

2. How does myricetin act in the body?

Myricetin acts by neutralising free radicals and reducing inflammation. Studies show that it can affect specific cellular pathways, which may help in slowing down cell damage.

3. Can myricetin decrease inflammation?

Yes, myricetin decreased inflammation in several studies, especially through its effects on cellular processes. It’s been observed to lower inflammatory markers, providing protective benefits to tissues and cells.

4. Has myricetin shown benefits for cancer-related inflammation?

Research targeting STAT1 by myricetin and delphinidin shows promise, as this pathway is linked to inflammatory responses involved in cancer. Myricetin’s action on STAT1 suggests potential benefits in reducing cancer-related inflammation.

5. Does myricetin have effects on oxidative stress?

Yes, myricetin reduced oxidative stress levels in multiple studies. By reducing free radicals, it supports cell resilience and overall health, particularly in tissues prone to oxidative damage.

6. What are some cellular impacts of isolated myricetin activity?

The activity of myricetin isolated in studies has shown promising results in protecting cells from inflammation and oxidative stress, which could support health at a cellular level over time.

7. Are there risks or side effects linked to myricetin?

In high doses, myricetin causes mild digestive discomfort in some individuals, though such effects are rare. It’s generally well-tolerated but should be approached with care for those with sensitive digestion.