Introducing our ultimate stack to boost NAD levels:
- Senolytic 8
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NMN (Nicotinamide Mononucleotide): As a precursor to NAD+, NMN plays a pivotal role in energy metabolism and DNA repair in cells. It's crucial for maintaining mitochondrial health, and there's a substantial body of research showing its potential to improve various aspects of health, primarily due to its role in restoring NAD+ levels, which decline with age.
Resveratrol: This compound has been extensively studied for its role in promoting cellular health. It's known for its antioxidant properties, ability to combat oxidative stress, and promotion of sirtuins, protein enzymes involved in cellular health and longevity. Resveratrol's ability to mimic caloric restriction effects, which are associated with a longer lifespan in various organisms, makes it a key inclusion.
Apigenin: Apigenin reduces inflammation and oxidative stress, two major contributors to the ageing of cells and tissues. It also has the ability to modulate key signalling pathways, such as those controlled by mTOR and AMPK, which are involved in cell growth, metabolism, and longevity. Furthermore, apigenin has been shown to enhance the body's detoxification processes, potentially protecting against age-related damage from environmental toxins.
Spermidine: Recognised for its ability to induce autophagy, the body's cellular renewal process, spermidine is critical for cellular cleansing and homeostasis. Studies show that it has broad health benefits, including promoting longevity due to its role in autophagy.
GlyNAC: This precursor to glutathione, the body's 'master antioxidant,' is vital for reducing oxidative stress within cells. It helps maintain appropriate glutathione levels, which are essential for detoxifying cells and combating free radicals, thereby protecting cells from damage and supporting their function.
Senolytic 8: This formula has been designed to target and induce the death of senescent cells that contribute to ageing and various age-related diseases. By clearing out these dysfunctional cells, senolytics help improve the cellular environment, enhancing the health and function of the remaining cells.
Ca-AKG: Calcium alpha-ketoglutarate (CA-AKG) plays an important role in the Krebs cycle, which is a critical energy-producing process that powers cellular function. As we age, levels of AKG naturally decline, which can lead to reduced cellular energy production and increased oxidative stress, both of which are hallmarks of ageing. CA-AKG has been shown to promote longevity by mimicking the effects of calorie restriction, activating anti-ageing pathways, and reducing inflammation. It helps maintain cellular health by supporting the body's natural DNA repair processes and by promoting the removal of cellular debris, which can accumulate and impair cell function. Additionally, CA-AKG has been linked to the regulation of gene expression related to ageing and the maintenance of stem cell health, which are vital for tissue regeneration and repair.