• Discover apigenin, a flavonoid found in chamomile tea and various plants, known for its anti-inflammatory effects, therapeutic potential, and dosage insights.

What is Apigenin? Therapeutic Potential of Apigenin, Dosage, and Side Effects

What is apigenin? This naturally occurring flavonoid, found in foods like chamomile, parsley, and celery, holds significant potential for health and longevity. Apigenin is known for its anti-inflammatory effects, antioxidant properties, and possible anti-cancer benefits.

Recent studies show that apigenin also supports cellular functions, such as increasing NAD+ levels and protecting brain neurovascular health, which may promote longevity. While dietary sources are beneficial, apigenin supplements offer a more concentrated dose.

The role of apigenin is diverse. It has been shown to modulate inflammation, inhibit cancer cell growth, and act as a mild sedative, promoting relaxation and improved sleep. Additionally, apigenin glycosides and other derivatives may enhance bioavailability, making this flavonoid more effective.

 Research has suggested that supplementing with apigenin, one might achieve benefits like reduced anxiety, improved mood, and better metabolic health, all contributing to longer, healthier living.

At Longevity Box, we take pride in offering supplements that are 99% pure, free from fillers, and backed by rigorous third-party testing. With over 100,000 satisfied customers, we’re committed to enhancing your well-being.

Interested in discovering more about this powerful flavonoid? Dive into our comprehensive guide on apigenin's potential benefits, dosage recommendations, and more.

What is Apigenin?

Apigenin is a naturally occurring flavonoid found in many fruits, vegetables, and herbs, including chamomile, celery, parsley, and thyme. It belongs to a group of plant-derived compounds known for their antioxidant, anti-inflammatory, and potential cancer-fighting properties. Among flavonoids, apigenin stands out due to its versatility and health-promoting effects.

By understanding what apigenin is, we can appreciate its role in promoting overall well-being and potentially supporting longevity. Apigenin works at a cellular level, influencing various biological processes, which we'll explore further in this article.

How Does Apigenin Work?

Apigenin exerts its benefits by interacting with multiple cellular pathways. It is known to:

• Act as an antioxidant by neutralising harmful free radicals, thus protecting cells from oxidative stress.
• Modulate inflammatory responses by inhibiting pro-inflammatory enzymes and cytokines, reducing inflammation in the body.
• Inhibit certain enzymes linked to cancer cell proliferation, making it a potential anti-cancer agent.
• Boost NAD+ levels, a vital coenzyme involved in energy production and cellular repair, essential for longevity.

In essence, apigenin’s ability to impact inflammation, oxidative stress, and NAD+ production makes it a potent compound for maintaining health and potentially promoting longevity. By supporting various bodily functions, apigenin may play a crucial role in improving overall wellness.

The Potential Health Benefits of Apigenin

Reduced Inflammation

Apigenin is celebrated for its strong anti-inflammatory properties. It suppresses key inflammatory enzymes and cytokines, reducing inflammation in the body. Chronic inflammation is often linked to various diseases, including autoimmune conditions, cardiovascular disease, and some cancers.

A study found that the administration of apigenin reduced inflammation markers in animal models,, showcasing its potential as a natural anti-inflammatory agent.

By reducing inflammation, apigenin not only supports overall health but may also slow down the ageing process, making it a valuable addition to any longevity-focused regimen.

Reduced Risk of Cancer

Research suggests that apigenin may offer protective benefits against certain cancers, including breast, prostate, and colon cancer. It achieves this by inhibiting the growth of cancer cells and promoting apoptosis (programmed cell death) in abnormal cells.

In one study, cancer cells treated with apigenin showed a significant decrease in proliferation, suggesting that apigenin may play a preventive role against cancer development.

Apigenin’s ability to target cancer cells while sparing normal cells further highlights its potential as a safe supplement for long-term health and disease prevention.

Enhanced NAD Levels

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme essential for energy production and DNA repair. As we age, NAD+ levels naturally decline, leading to decreased cellular function and energy. Apigenin has been shown to inhibit CD38, an enzyme that depletes NAD+.

Animal studies suggest that apigenin increases NAD+ levels, supporting cellular energy and longevity.

Boosting NAD+ with apigenin may enhance energy production, promote healthy ageing, and improve overall vitality.

Reduced Feelings of Anxiety

Apigenin’s mild sedative effect is well-documented, making it a popular choice for reducing anxiety. It works by binding to specific receptors in the brain, promoting a calming effect without the sedative side effects associated with some medications.

Researchers have reported the anti-anxiety effects of apigenin in animal models, demonstrating its potential as a natural anxiolytic.

Incorporating apigenin into a daily routine may support mental well-being, contributing to a more relaxed state of mind.

Reduced Feelings of Depression

Apigenin may also help alleviate symptoms of depression by modulating neurotransmitter levels in the brain, specifically increasing the availability of serotonin and dopamine.

In one animal study, mice treated with apigenin exhibited behaviours associated with improved mood and decreased depression-like symptoms.

Improving mental health naturally contributes to a longer, healthier life by reducing stress-related risks.

Lower Cholesterol and Obesity Prevention

Apigenin has been linked to lowering cholesterol levels and preventing obesity. It influences lipid metabolism, helping to reduce bad cholesterol levels and potentially prevent fat accumulation.

Research showed that a diet containing apigenin led to reduced cholesterol levels and body fat in animal models, indicating its potential for weight management and metabolic health.

Maintaining a healthy weight is crucial for longevity, as it reduces the risk of various chronic diseases, including cardiovascular disease and diabetes.

Protection from Oxidative Stress

Oxidative stress, caused by an imbalance of free radicals and antioxidants, accelerates ageing and damages cells. Apigenin’s antioxidant properties help neutralise free radicals, reducing oxidative damage to cells.

A study found that apigenin protects brain cells from oxidative damage, highlighting its potential in neuroprotection and cognitive health.

By combating oxidative stress, apigenin supports healthy ageing and the prevention of age-related diseases.

Relief from Rheumatoid Arthritis

Apigenin’s anti-inflammatory properties may benefit individuals with rheumatoid arthritis by reducing joint inflammation and pain. It inhibits specific inflammatory pathways associated with this autoimmune disease.

In animal models, apigenin was found to reduce joint swelling and inflammation, providing potential relief from rheumatoid arthritis symptoms.

Reducing inflammation in joints can improve mobility and overall quality of life, contributing to healthier ageing.

Treatment of Autoimmune Disease

Apigenin's ability to modulate immune responses may be beneficial in treating autoimmune diseases. It can reduce the overactive immune response that characterises these conditions.

Studies have shown that apigenin inhibits autoimmune markers, indicating its potential as a supportive treatment for autoimmune diseases.

By managing autoimmune reactions, apigenin promotes a balanced immune system, supporting overall longevity.

Prevention of Neurodegenerative Disease

Apigenin has neuroprotective effects that may help prevent neurodegenerative diseases like Alzheimer’s and Parkinson’s. It combats oxidative stress and inflammation, two key factors in the progression of these conditions.

Research indicates that apigenin promotes brain cell survival in animal models, making it a potential preventive measure against neurodegenerative diseases.

Supporting brain health is a crucial aspect of maintaining cognitive function and promoting a longer, healthier life.

Treatment of Migraines

Apigenin may help alleviate migraines by reducing inflammation and relaxing blood vessels, which can improve blood flow and decrease pain.

Some studies have found that apigenin is able to reduce migraine frequency and intensity, suggesting its potential role as a natural treatment.

Effective migraine management can enhance quality of life, contributing to overall well-being and longevity.

Improved Sleep

Apigenin’s sedative effects make it a popular natural remedy for sleep issues. By promoting relaxation and reducing anxiety, apigenin can improve sleep quality and duration.

Studies have demonstrated that apigenin improves sleep patterns in animals, supporting its use as a natural sleep aid.

Improved sleep is linked to better overall health, reduced risk of chronic diseases, and longer lifespan, making apigenin a valuable addition to a sleep-supporting regimen.

Apigenin offers a wide range of potential health benefits, from reducing inflammation and improving mental well-being to enhancing NAD+ levels and supporting neuroprotection. As a natural supplement, it aligns with the goals of promoting longevity and healthy ageing. Incorporating apigenin into a balanced lifestyle, whether through diet or supplementation, may support a longer, healthier life.

Overview of potential apigenin health benefits:

• Reduced Inflammation
• Reduced Risk of Cancer
• Enhanced NAD Levels
• Reduced Feelings of Anxiety
• Reduced Feelings of Depression
• Lower Cholesterol and Obesity Prevention
• Protection from Oxidative Stress
• Relief from Rheumatoid Arthritis
• Treatment of Autoimmune Disease
• Prevention of Neurodegenerative Disease
• Treatment of Migraines
• Improved Sleep

Potential Health Risks and Side Effects of Apigenin

Apigenin is generally regarded as a safe and well-tolerated supplement, even when consumed in higher doses. It is a naturally occurring flavonoid found in various foods, making it a familiar compound to the human body. However, like all supplements, it is not entirely free of risks or side effects, especially when taken in large doses or for extended periods.

Common Side Effects

While apigenin is considered safe for most individuals, some may experience mild side effects, such as:

• Digestive Upset: Some people might experience mild gastrointestinal discomfort, such as bloating, nausea, or diarrhoea, particularly when starting supplementation.
• Drowsiness: Given apigenin’s sedative effects, especially when derived from chamomile extract or consumed as chamomile tea, it may cause drowsiness. This effect, however, could be beneficial for those seeking improved sleep.
• Allergic Reactions: Individuals with allergies to plants in the Asteraceae family (e.g., chamomile, marigold, ragweed) should exercise caution, as apigenin is one of the key compounds in these plants.

Safety Considerations

• Pregnancy and Breastfeeding: There is limited research on the safety of apigenin during pregnancy and breastfeeding. It is best to consult a healthcare provider before using apigenin supplements in these conditions.
• Interaction with Medications: Apigenin may interact with certain medications, such as blood thinners, sedatives, or anti-anxiety drugs, due to its mild sedative properties and potential to affect blood clotting.

Although the protective effects of apigenin outweigh the risks for most users, it is wise to start with a low dose and gradually increase to the recommended dosage while monitoring any side effects. Always consult with a healthcare professional before beginning a new supplement, especially if taking other medications.

Which Foods Contain Apigenin Naturally?

Apigenin is abundantly present in a variety of fruits, vegetables, and herbs, making it accessible through a well-rounded diet. Some of the best dietary sources include:

• Chamomile: Chamomile tea is one of the most well-known sources of apigenin. Consuming it regularly can provide a significant amount of this flavonoid.
• Parsley and Celery: Both herbs contain high concentrations of apigenin. Parsley, in particular, is often cited as having some of the highest levels among common foods.
• Oranges: Although less concentrated than chamomile or parsley, oranges and orange juice still offer a notable source of apigenin.
• Spinach: This leafy green contains apigenin along with other flavonoids that contribute to its health benefits.
• Thyme and Oregano: These herbs are also rich in apigenin, making them excellent additions to meals for boosting flavonoid intake.

Including apigenin-rich foods in the diet not only provides this potent flavonoid but also offers additional nutrients and antioxidants that support overall health and longevity. Regular consumption of such foods, along with other flavonoids like quercetin and apigenin, can enhance the body’s defence against inflammation, oxidative stress, and even the development of breast cancer cells.

Apigenin Supplements and Dosage: What You Need to Know

While dietary sources of apigenin offer natural benefits, supplements like this one provide a 100 mg dose of pure apigenin, making it a concentrated and convenient way to achieve your wellness goals. This supplement supports specific health needs such as sleep support, relaxation, anxiety reduction, and inflammation management.

Dosage

The recommended dosage of apigenin varies according to individual health needs and goals. Common guidelines include:

• 100 mg of apigenin daily: This standard dose, provided per capsule on this product page, is formulated to support sleep, relaxation, and overall well-being. For those seeking additional benefits, such as inflammation reduction, this dose remains a reliable option.
• 200 mg of apigenin daily: For more targeted outcomes, such as addressing inflammation or other specific health concerns, taking two capsules (200 mg) per day can be considered.

It's recommended to start with one capsule (100 mg) daily and increase gradually as needed, based on personal response and tolerance. This approach helps manage potential side effects while optimising benefits.

Frequency

Apigenin can be taken once or twice daily, depending on the desired effects:

• Evening dose: A single 100 mg capsule in the evening is suitable for promoting sleep and relaxation.
• Twice-daily dose: For more comprehensive health support, like inflammation management, taking 100 mg twice daily can maintain consistent apigenin levels.

Adding this supplement to a broader wellness regimen, potentially alongside other complementary flavonoids, may enhance its overall effectiveness.

Conclusion

Apigenin is a flavonoid that has shown considerable promise for health and longevity. This naturally occurring compound, found in foods like chamomile and parsley, interacts with various biological pathways, supporting the body’s natural defences. Studies on apigenin suggest its potential to reduce inflammation, improve NAD+ levels, and even offer neuroprotection. The combination of apigenin with other flavonoids like luteolin may enhance these effects. Its inhibitory impact on oxidative stress, along with possible benefits against certain cancers, makes it a significant focus in longevity research.

Apigenin has also been associated with better mental well-being, showing antidepressant-like effects. It promotes relaxation and could contribute to better sleep, further supporting overall health. The activity of apigenin extends to other benefits, including its role as an inhibitor of certain enzymes linked to inflammation and cancer cell growth. While it is generally well-tolerated, the bioavailability of apigenin varies depending on the form used, with supplements often providing a more concentrated dose.

The potential of apigenin to prolong longevity via mitohormesis and protect brain health is especially noteworthy. Whether consumed through diet or supplements, regular intake of apigenin could support a healthier, longer life. For those looking to integrate this potent flavonoid into their wellness routine, it's a straightforward yet impactful step towards better health.

To explore more about apigenin and its potential benefits, visit Longevity Box and discover how this natural compound could fit into your wellness journey.

FAQ

• What are the main health effects of apigenin?
  
  
• Apigenin is a natural flavonoid known for its anti-inflammatory, antioxidant, and neuroprotective properties. It may significantly reduce inflammation, improve brain health, and potentially inhibit cancer cell growth.
  
  
• How does apigenin interact with other flavonoids like luteolin?
  
  
• Apigenin and luteolin, both flavonoids, can work together to amplify anti-inflammatory and antioxidant effects. This combination of apigenin may provide better overall health benefits.
  
  
• Is apigenin an inhibitor of specific enzymes?
  
  
• Yes, apigenin is an inhibitor of certain enzymes linked to inflammation and cancer. This inhibitory effect of apigenin can play a role in reducing the progression of diseases and supporting longevity.
  
  
• Are there different forms or derivatives of apigenin?
  
  
• Yes, apigenin derivatives, like those found in dietary supplements, can improve bioavailability, making the flavonoid more effective. Apigenin and naringenin are often found together, with apigenin sometimes oxidising naringenin in biological processes.
  
  
• How effective is apigenin in cancer prevention?
  
  
• Apigenin has also been reported to inhibit the growth of cancer cells, particularly when exposed to apigenin at concentrations of 2.5 mg. It shows effects on both normal and cancerous cells, with the flavonoid suppressing tumour growth.
  
  
• Does apigenin have an impact on mental health?
  
  
• Yes, antidepressant-like effects of apigenin have been observed. It may improve mood and promote relaxation, contributing to better mental well-being and potentially enhancing sleep quality.
  
  
• Can apigenin support longevity?
  
  
• Evidence suggests that apigenin, along with other flavonoids like chrysin, can prolong longevity via mitohormesis, a process that enhances mitochondrial function. Studies on both apigenin in humans and apigenin in rats indicate promising results for healthy ageing.