A study published in Frontiers in Nutrition in 2022 has improved our understanding of how we can combat aging, specifically looking at the effects of an orally administered supplement, Nicotinamide Mononucleotide (NMN), on human subjects. NMN operates as an NAD+ precursor and has been found to counteract the effects of aging and age-related diseases, including obesity, heart failure, and Alzheimer's disease, in animal models. This study serves as one of the first to provide empirical evidence that NMN supplementation might present similar benefits for human health. The study can be found here.
The experiment was conducted by administering 250 mg/day of oral NMN to 15 healthy subjects and a placebo to 15 other subjects, for a period of 12 weeks. Over the course of the study, physiological markers and blood tests were carried out to track any effects of the supplement. The data showed that no abnormalities or adverse effects arose from the oral uptake of NMN over the 12-week period. The supplement didn't cause any consternation in physiological markers, and laboratory tests returned normal results.
Most importantly, the study revealed a statistically significant increase in the levels of NAD+ in the subjects' blood circulation after the oral administration of NMN. This communication molecule, or metabolite, NAD+, plays a critical role in various biological processes, such as metabolism, DNA repair, stress response, and gene expression. Moreover, the researchers also discovered an uptick in nicotinic acid mononucleotide (NAMN) levels, although NMN levels remained unaffected.
Surprisingly, the increase in NAD+ levels seemed to correlate strongly with pulse rates prior to the oral administration, suggesting that NMN supplementation might have a more pronounced effect on individuals with certain physiological traits.
Taken together, these findings validate the safety and efficiency of oral NMN administration as a way of increasing NAD+ levels in humans, pointing to a potential breakthrough in the fight against aging and age-related diseases.
Key Takeaways:
- Conducted in 2022, this study is one of the very few that demonstrates the effects of NMN supplementation in human health.
- The research confirmed the safety and efficacy of oral NMN supplementation over a 12-week period, causing no abnormalities in physiological and laboratory tests.
- The experiment showed that NMN supplementation significantly increased levels of NAD+, a critical molecule involved in numerous biological processes.
- The study found an increased NAD+ level correlating strongly with pulse rates before the administration of NMN.
- These findings suggest that NMN could serve as an effective and safe strategy to augment NAD+ levels and fight aging and age-related diseases.