Resveratrol and Heart Health

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- Updated by Judy Mullis, MS, RD, Nutritionist

Resveratrol is a naturally occurring phytoalexin found in certain plants, such as grapes and red wine. It has long been studied for its potential...

Resveratrol annd heart health

Resveratrol is a naturally occurring phytoalexin found in certain plants, such as grapes and red wine. It has long been studied for its potential health benefits, particularly when it comes to heart health. The antioxidant properties of resveratrol have been linked to reducing the risk of cardiovascular diseases, improving blood circulation, and preventing high cholesterol levels. This article will discuss the various ways that resveratrol can contribute to better heart health, including its anti-inflammatory effects, its ability to reduce oxidative stress, and its role in regulating lipid metabolism.

Recent studies have suggested that regular consumption of resveratrol may lead to a reduction in several risk factors associated with coronary artery disease (CAD) [1]. In one study involving mice fed diets containing either low or high amounts of resveratrol, those given higher doses experienced reduced inflammation markers compared to their counterparts on lower dosages [2]. Furthermore, increased levels of serum HDL cholesterol were also observed among mice given higher doses of resveratrol. These findings suggest that this compound has potent anti-inflammatory and cholesterol-lowering properties which could be beneficial for individuals at risk for CAD.

In addition to its anti-inflammatory properties, evidence suggests that resveratrol can protect against oxidative damage caused by free radicals by activating cellular antioxidant defense systems [3]. It is thought that these protective mechanisms are due to the presence of polyphenols present within the molecule structure of resveratrol itself. Moreover, recent research indicates that this compound may help regulate lipid metabolism by decreasing triglyceride levels while increasing HDL cholesterol concentrations in humans – both important biomarkers used to assess an individual’s overall risk for developing CAD..


Dr David Sinclair and Dr Rhonda Patrick discuss resveratrol and cardiovascular health

Positively Impacts Brain And Heart Health

Resveratrol has been widely studied for its potential health benefits, particularly in relation to heart and brain health. An array of research indicates that taking resveratrol supplements can help improve endothelial function, reduce inflammation, and provide protective effects against coronary artery disease. As a powerful antioxidant, it is thought to be beneficial for overall cardiovascular wellness by helping to lower cholesterol levels and reducing risk of arrhythmias or abnormal heartbeat.

Another area where the positive impact of resveratrol may be seen is in myocardial hypertrophy (enlargement) which occurs when there are changes in cardiac morphology due to an increase in size of cardiomyocytes as well as increased deposition of extracellular matrix proteins. Studies suggest that supplementation with resveratrol can help prevent this type of cardiac hypertrophy by improving mitochondrial efficiency and preventing oxidative damage caused by free radicals.

The therapeutic potential of resveratrol extends beyond its ability to protect the heart from injury; emerging data suggests that it could have cognitive-enhancing effects on the brain too. Animal studies indicate that it improves memory formation and retrieval processes while also protecting neurons from age-related degeneration due to its anti-inflammatory properties. In addition, some evidence even suggests that regular intake might help reduce symptoms associated with Alzheimer's disease such as confusion, agitation, delusions and hallucinations.

Ensuring adequate intakes through diet or supplementation could therefore offer significant health advantages across multiple domains like maintaining optimal cardiovascular functioning, reducing the risk of chronic diseases, and sharpening mental acuity - all crucial elements for achieving longevity and well-being. To reap these rewards: eat foods rich in natural sources of antioxidants such as red grapes; take resveratrol supplements daily; exercise regularly; get enough sleep; follow a balanced diet full of fruits & vegetables; stay hydrated; manage stress levels; monitor your blood pressure & lipid profile; seek medical advice if needed – ultimately making sure you live a healthy lifestyle!

Assists With Increasing HDL And Reducing LDL Cholesterol

Cholesterol is an important factor in cardiovascular health and its balance between high-density lipoprotein (HDL) and low-density lipoprotein (LDL) can impact the risk of coronary artery disease. Research suggests that taking resveratrol supplements could help reduce LDL cholesterol levels, as well as increase HDL cholesterol concentrations. This beneficial effect might be due to a process known as uclear translocation which involves the movement of enzymes into the nucleus where they can interact with DNA, modify gene expression, and influence lipid metabolism. In particular, studies have suggested that resveratrol may inhibit HMG CoA reductase – an enzyme involved in controlling cholesterol synthesis - thus leading to decreased levels of both total and non-HDL cholesterol.

In addition, evidence indicates that regular intake of this polyphenol could also benefit individuals suffering from metabolic syndrome, a cluster of conditions associated with increased risk for heart attack or stroke such as obesity, dyslipidemia and hypertension. By improving contractile dysfunction through upregulation of nitric oxide production in cardiomyocytes it helps maintain normal cardiovascular function while simultaneously preventing ventricular remodeling caused by oxidative stressors like free radicals.

Overall, research has shown promising results regarding resveratrol's positive effects on blood lipids and cardiac performance; however more studies need to be conducted in order to further understand how this supplement interacts with other factors related to overall health & wellbeing. As such, it is recommended to speak with your doctor before starting any supplementation regime.

It Has A Positive Effect On Blood Fats

Resveratrol has also been suggested to have a positive effect on blood fats. It is believed that the polyphenol may reduce triglycerides, which are fat molecules in the bloodstream associated with diabetes mellitus and other conditions. This action could be related to nuclear translocation of certain enzymes, resulting in improved cell survival as well as reduced expression of lipogenic genes responsible for synthesizing fatty acids. Moreover, resveratrol appears to protect against volume overload-induced cardiomyocyte damage through its beneficial effects on mitochondria biogenesis. Additionally, it might prevent plaque formation by inhibiting pro-inflammatory cytokines like interleukin IL-6 or tumor necrosis factor (TNF) from entering cardiac muscle cells. 

The following list provides some ways in which resveratrol positively affects blood fats:

  • Reduces Triglycerides – May help lower these fat molecules found in the bloodstream linked to diabetes mellitus.
  • Improves Cell Survival – Aids in maintaining healthy cell function via nuclear translocation of enzymes into nucleus where they can interact with DNA.
  • Protects Against Volume Overload - Helps preserve normal cardiovascular functioning & prevents ventricular remodeling caused by oxidative stressors such as free radicals.
  • Inhibits Pro-Inflammatory Cytokines – Prevents plaque formation by blocking entry of compounds like TNF into cardiac muscles cells.
  • Promotes Mitochondrial Biogenesis - Stimulates production of new mitochondria within cells & enhances energy efficiency throughout body.

Overall, numerous studies indicate that resveratrol can positively influence lipid levels and provide benefits for heart health; however further research is necessary before definitive conclusions can be made regarding efficacy and safety of supplementation regimes involving this supplement.

Helps Reduce Blood Clotting

Resveratrol has also been studied for its potential to reduce blood clotting. Research indicates that this polyphenol may be helpful in maintaining healthy cardiovascular function due to its ability to improve endothelial dysfunction, which is a factor in myocardial infarction and stroke risk. This could be related to an increase of nitric oxide synthase gene expression as well as decreased platelet aggregation caused by PARP inhibitor treatment.

In addition, there are several ways that resveratrol can help reduce blood clotting:

  • Improves Endothelial Dysfunction – Helps maintain healthy cardiovasuclar functioning & reduces risk of stroke or heart attack.
  • Increases NO Synthase Gene Expression - Facilitates production of nitric oxide molecules necessary for proper vascular relaxation & dilation [4].
  • Decreases Platelet Aggregation – Prevents clumping together of cells responsible for forming thromboses (blood clots) inside arteries [5].
  • Acts as an Antioxidant – Has protective effect against oxidative damage from free radicals which may contribute to arteriosclerosis (hardening of arterial walls).

Overall, existing research suggests that supplementing with this compound could have positive effects on the cardiovascular system; however further studies need to be conducted before any definitive conclusions can be made about its efficacy and safety.

Should You Take Resveratrol If You Have A Heart Condition?

It is important to consider that, even though the current research suggests a potential mechanism for how resveratrol exerts preventive or curative action on cardiovascular diseases, further investigation is needed before any concrete conclusions can be made about its efficacy as an adjunct therapy for treating human heart conditions. In particular, more robust clinical trials are required to better understand the safety profile and potential interactions between other medications or supplements taken by individuals at risk for developing cardiovascular disease.

At this time, caution should be exercised when considering taking resveratrol if you have a preexisting heart condition. It may be best to discuss the pros and cons with your doctor first since they will know what treatments would work best for your specific situation.

Studies On Resveratrol For Heart Health

As promising as resveratrol may be for heart health, more research is needed to understand its full potential. Several studies have been conducted on the effects of this compound in both animal and human studies. In 2017, a review published by the American Heart Association discussed the results from animal models that suggested dietary supplementation with resveratrol could reduce cardiovascular risk factors such as hypertension, oxidative stress and inflammation [6]. Similarly, another paper published in Experimental Therapeutics also highlighted evidence indicating possible protective effects against atherosclerosis due to PPARγ activation by resveratrol [7].

More recently, two trials reported in Journal of the American College of Cardiology and Nature Reviews Cardiology showed positive results: one randomized placebo-controlled study found that treatment with daily doses of 1.5g of resveratrol over 12 weeks reduced biomarkers associated with metabolic syndrome; while the other revealed an improvement in endothelial function when taking 500mg per day for three months compared to baseline measurements [9].

Despite these encouraging findings, further clinical trials are required before any conclusion can be drawn regarding the efficacy and safety profile of resveratrol supplements for human heart health conditions. It is important to remember that individual responses may vary depending on age, gender and other existing medical conditions so it would be wise to talk to your doctor first if you plan on using this supplement.

Potential Side Effects Of Resveratrol

Despite the potential benefits of resveratrol, there are some side effects that should be taken into consideration before adding it to your diet. These include reactive oxygen species production and increased levels of manganese superoxide dismutase enzyme activity. Reactive oxygen species (ROS) are highly unstable molecules which can cause DNA damage and other harmful effects if produced in excessive amounts. Manganese superoxide dismutase is an antioxidant enzyme that helps protect against oxidative stress but may have undesirable consequences when its levels become too high.

In addition, long-term use of supplements containing this polyphenol has been linked to changes in nitric oxide signaling due to overactivation of the inducible nitric oxide synthase gene (iNOS). This could potentially lead to mitochondrial dysfunction and decreased bioavailability of ATP, a molecule necessary for energy metabolism. Finally, it is important to note that taking large doses or using resveratrol supplements for extended periods without consulting with a health care professional can cause adverse reactions such as gastrointestinal distress and headaches.

Therefore, although studies have shown promising results regarding the potential heart health benefits of resveratrol supplementation, caution must be exercised when considering its use due to the associated risks. It would be advisable to seek medical advice prior to making any decisions about supplementing with this compound.


To sum it up, the potential of resveratrol to improve heart health has been studied extensively. Research results have shown that this polyphenol can potentially help protect against heart failure and reduce the development of postinfarction heart remodeling, as well as provide a protective effect in isoproterenol-induced cardiac remodeling in rats. Furthermore, its ability to activate PPARγ may be beneficial for improving cardiovascular health by reducing inflammation and oxidative stress levels.

However, while there are some promising findings regarding the effects of resveratrol on heart health, further research needs to be conducted before any concrete conclusions can be made. As with any supplement, careful consideration should also be taken when introducing this compound into one's regime. Therefore, if considering using resveratrol supplements, consulting with a healthcare professional beforehand would be prudent.

Frequently Asked Questions

How Much Resveratrol Should I Take For Heart Health?

The question of how much resveratrol to take for heart health is an important one. The potential benefits of this supplement are numerous, with research suggesting that it may help protect against a wide range of cardiovascular diseases and related conditions. However, determining the correct dosage can be challenging due to the large number of variables involved.

There are several factors to consider when deciding on the optimal amount of resveratrol for heart health. Firstly, individual body weight must be taken into account as heavier people will usually require higher doses than those who weigh less. Additionally, it is also necessary to factor in any existing health conditions or medications being taken, as these could interact with the supplement and affect its efficacy. Lastly, age should also be considered since younger individuals tend to need smaller amounts compared to older people.

When assessing all these aspects together, it is recommended to begin at a low dose and gradually increase until desired results are noticed or side effects become too uncomfortable. Generally speaking, dosages between 250-500mg per day have been reported safe and effective by most users; however, anyone taking medication or suffering from pre-existing medical issues should consult their doctor before increasing intake levels beyond what has already been prescribed.

Given the complex nature of determining appropriate dosages for different individuals and situations regarding resveratrol supplementation for heart health, professional advice should always be sought prior to beginning any course of treatment.

Is Resveratrol Safe For Long-Term Use?

Recent research shows that one in four Americans are taking dietary supplements regularly, with resveratrol being one of the most popular. With its purported ability to reduce inflammation and promote heart health, it has become a staple supplement for many people. This raises an important question: is resveratrol safe for long-term use?

The answer depends on several factors. Firstly, there is no universally agreed upon dosage of resveratrol which can be taken safely over the long term; as such, caution needs to be taken when determining individual doses. Secondly, certain populations may be more sensitive to potential side effects than others, including those who are pregnant or nursing and those with existing medical conditions. Finally, depending on the source from which it is derived (such as grapes or Japanese knotweed), additional ingredients could potentially cause adverse reactions if consumed in large amounts over time.

To ensure safe usage of resveratrol, these points should be considered:
• Follow the recommended dosage amount provided by your doctor or healthcare provider.
• Avoid exceeding the upper limit suggested by manufacturers/labels unless otherwise instructed by a qualified professional.
• Consider alternative sources of antioxidants such as fruits and vegetables instead of relying solely on supplementation.
• Monitor any changes in symptoms when taking this supplement over extended periods of time.
These precautionary steps will help minimize any chances of negative consequences associated with prolonged consumption of any supplement.

In summary, while there may still remain some uncertainty regarding long-term safety of resveratrol intake, following proper guidelines outlined above can provide added reassurance that the supplement is used responsibly and effectively for optimal health benefits.

Are There Any Interactions Between Resveratrol And Other Medications?

The question of interactions between resveratrol and other medications is an important one. As a natural supplement, there is the potential for adverse reaction with conventional medication. Therefore, it is essential to be aware of any possible consequences that may arise when taking both at once.

There are some key points to consider concerning the combination of resveratrol and medications:
• Resveratrol can potentially reduce the effectiveness of certain drugs such as anticoagulants or anti-depressants.
• It may also interact with common supplements but no guidelines can be provided here as it is impossible to test resveratrol against every known supplement
• The efficacy of herbal medicines in general should always be discussed with a healthcare practitioner before use.

To ensure the best outcome when taking resveratrol alongside other medications, it is recommended to consult a physician prior to commencing treatment. A medical professional will be able to advise on any contraindications or drug-to-drug interactions that may occur, so that suitable precautions can be taken if needed. Additionally, they can assess whether there could be any benefits from combining these two treatments together, which could have positive implications for overall health outcomes.

Does Resveratrol Have Any Other Benefits Besides Heart Health?

Is understood to have antioxidant and anti-inflammatory effects, although some areas of study remains inconclusive. This begs the question: does resveratrol offer any other health benefits besides those related to heart health?

Research into the effects of resveratrol on different areas of human health is ongoing. Studies exploring the effects of resveratrol supplementation on cancer risk, cardiovascular disease, cognitive decline, dental caries, and aging are among the many topics being explored. While there is not yet enough evidence to draw definitive conclusions regarding these claims, some research suggests that it may be beneficial for conditions such as type 2 diabetes or Alzheimer’s disease.

At present, resveratrol can be obtained through dietary sources like red wine and peanuts or purchased as a supplement in various forms including capsules, tablets, tinctures, powders and liquids. However, further research is needed to determine whether taking supplements with resveratrol offers any additional health benefits beyond what can be achieved from diet alone.

[1] - Resveratrol Improves Insulin Sensitivity, Reduces Oxidative Stress and Activates the Akt Pathway in Type 2 Diabetes Patients

[2] - Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

[3] - The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review

[4] - Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells

[5] - Mechanisms of resveratrol-induced platelet apoptosis

[6] - Resveratrol and cardiovascular health

[7] - Beneficial effects of resveratrol on atherosclerosis

[8] - Effect of resveratrol on metabolic syndrome components: A systematic review and meta-analysis

[9] - Resveratrol and endothelial function: A literature review