Why This Matters to Us
For those passionate about longevity and quality of life, María’s life offers a unique case study. Her ability to reach 117 years in good health aligns with several core ideas within longevity science. From the importance of gut health and reduced inflammation to the role of social connections, her life validates many theories about ageing and offers actionable habits for those seeking to increase both their lifespan and healthspan.
María’s example demonstrates how combining good genetic fortune with lifestyle interventions—many of which are within our control—can pave the way for a longer, healthier life. For longevity enthusiasts, her story provides both inspiration and scientific grounding for incorporating these habits into everyday life.
The Detail
María Branyas Morera, born in 1907, passed away in 2024 at 117 years old. Her extraordinary lifespan placed her among the few verifiable supercentenarians in history. While genes were significant—many of her family members lived beyond 90—her lifestyle, habits, and physiological profile played major roles in her longevity.
Gut Health and Longevity
Scientists studying María discovered that her gut microbiome was unique. Her digestive system contained five times the usual amount of Bifidobacterium, a beneficial gut bacterium linked to reduced inflammation and improved overall health. These microbes play a critical role in ageing by managing chronic inflammation, which has been connected to diseases like arthritis, heart problems, and cognitive decline.
María’s gut health might be tied to her consumption of three yoghurts daily. These yoghurts contained probiotics, which promote the growth of Bifidobacterium and other beneficial bacteria in the gut. Research shows probiotics may improve digestion, boost immunity, and even influence brain health.
Learn more about María’s gut health in this linked study.
Genetics and Biological Age
Apart from gut health, María’s genes offered her a significant advantage. Researchers found she carried seven rare genetic variants present in fewer than 1.5% of people of European heritage. These variants affect immune function, cognition, and the health of mitochondria—tiny power factories in our cells. Healthy mitochondria are essential for energy production and cell repair, both of which slow ageing.
Interestingly, when her biological age (how "old" her cells appeared) was tested using DNA methylation markers, it turned out to be 10–30 years younger than her actual age. This test measures chemical changes to DNA, showing how “well” someone’s body has aged. María’s slower-than-average ageing process likely contributed to her long life.
The Impact of Lifestyle
While genetics gave María an edge, her everyday habits amplified her health. She never drank alcohol or smoked, and she favoured light, nutritious meals over large portions. This aligns with research into caloric restriction, which suggests that eating fewer calories while maintaining proper nutrition can enhance cellular repair and slow ageing.
Her diet primarily consisted of Mediterranean staples—fruits, vegetables, whole grains, olive oil, and fish. This dietary pattern is associated with lower risks of heart disease, Alzheimer’s, and other age-related conditions.
The Power of Social and Emotional Well-being
María attributed much of her longevity to positivity and strong relationships. She avoided toxic people and surrounded herself with supportive family and friends. Close relationships, as seen in “Blue Zones” (regions with the longest-living populations), foster a sense of purpose and reduce chronic stress, which significantly accelerates ageing.
Furthermore, María practiced letting go of regrets and focusing on the present. This mindset aligns with research showing that optimism and stress management can improve both mental and physical health, enhancing longevity.
Longevity Lessons to Incorporate
María’s life leaves us with actionable insights for promoting a long and healthy life:
- Improve Gut Health: Incorporate probiotic-rich foods like yoghurt into your diet to support beneficial gut bacteria.
- Prioritise Relationships: Build and maintain strong, positive connections with family and friends to support emotional and physical health.
- Adopt a Balanced Diet: Follow Mediterranean-style eating habits with an emphasis on whole, nutritious foods and smaller portions.
- Stay Active: Physical activity, like her daily walks, promotes cardiovascular and overall health.
- Focus on Positivity: Manage stress, avoid negativity, and embrace a mindset that values optimism and living without regrets.
- Avoid Harmful Habits: Minimise alcohol and tobacco use.
María’s unique balance of genetic benefits and intentional lifestyle choices offers a roadmap for anyone seeking longevity. By adopting her habits—focusing on gut health, fostering meaningful relationships, and embracing a positive outlook—we can edge closer to a healthier, longer life while enjoying each step of the journey. For more details on María’s inspiring story, click here.