Nicotinamide Riboside: Benefits for Cellular Health & Energy

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- Updated by Jody Mullis
Medically reviewed by Dr. Sidra Samad

Discover the power of Nicotinamide Riboside (NR) for boosting cellular health and energy. Learn about its benefits, side effects, and dosage for optimal results.

The Benefits of Nicotinamide Riboside for Improved Cellular Health and Energy Production

Have you ever wondered how to boost your energy and support cellular health as you age? Nicotinamide riboside (NR), a form of vitamin B3 known scientifically as nicotinamide riboside chloride, might be the answer. This dietary supplement, known for its ability to increase NAD levels, offers numerous benefits, particularly for healthy middle-aged and older adults.

NR is uniquely and orally bioavailable, making it an effective NAD precursor. Research has shown that nicotinamide riboside can significantly boost NAD metabolism, which is essential for energy production and cellular repair. The administration of nicotinamide riboside increases NAD levels, promoting better health and vitality. For instance, using high-quality NR supplements can effectively boost NAD levels, enhancing your overall well-being.

Studies indicate that NR improves blood NAD levels, supporting various metabolic processes. This effect is seen even with a single oral administration of NR. The beneficial effects of NR are evident in its role in boosting energy, improving cognitive function, and supporting overall cellular health.

Furthermore, NR and nicotinamide mononucleotide (NMN) are both important precursors of NAD. Both compounds play crucial roles in NAD metabolism and have been shown to raise NAD levels effectively. However, NR is particularly noteworthy for its efficiency and bioavailability, making it a popular choice among NAD supplements.

Understanding the science behind NR and its benefits for cellular health is crucial. Nicotinamide riboside augments the aged by boosting NAD levels and supporting various essential functions in the body. Research has demonstrated that NR can significantly improve blood NAD levels, promoting better energy metabolism and overall vitality.

Committed to health and longevity since 2021, Longevity Box offers purity-guaranteed supplements to over 100,000 satisfied customers. Our products undergo rigorous third-party testing to ensure they are free from fillers, binders, and preservatives, providing a reliable option for enhancing your NAD levels and overall well-being.

What Is Nicotinamide Riboside (NR)?

Nicotinamide riboside is a form of vitamin B3, known for its ability to act as a precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is a coenzyme involved in various metabolic processes essential for energy production and cellular repair. NR is unique as it can be taken orally and effectively converted to NAD+ in the body.

Unlike its counterparts, nicotinamide and niacin, NR stands out due to its efficient conversion to NAD+. This conversion happens through two pathways, facilitated by enzymes such as nicotinamide riboside kinase. Consequently, NR supplementation is gaining popularity for its potential health benefits.

Where is NR Found?

NR occurs naturally in small amounts in foods such as:

  • Milk
  • Fish
  • Yeast
  • Vegetables

Benefits of Nicotinamide Riboside

Research suggests that NR may benefit various health aspects:

Safety and Dosage

Taking NR is likely safe with minimal side effects. Human studies have shown that dosages of 250-1,000 mg per day are generally well-tolerated, although most studies have been short-term. The long-term safety profile is still under investigation.

NR can potentially be combined with other NAD+ precursors such as nicotinic acid to enhance its benefits. This synergy can accelerate the conversion of NR to NAD+.

How Nicotinamide Riboside Works in the Body

Nicotinamide riboside takes centre stage by being a derivative of vitamin B3. When ingested, it is converted into NAD+, a coenzyme found in all living cells. This coenzyme plays a pivotal role in energy metabolism and several other cellular processes.

Boosting NAD+ Levels: One of NR’s primary functions is increasing NAD+ levels. This increased NAD+ concentration helps cells to produce energy more efficiently. As NAD+ levels decline with age, supplementation with NR can assist in maintaining proper energy metabolism.

NAD+ Metabolism: NAD+ is involved in various metabolic pathways, including those responsible for the crafting of ATP, the energy currency of the cell. NR enhances these pathways by providing additional resources for NAD+ synthesis. This is essential for metabolic health.

Administration of NR: The consumption of NR is generally safe, even in higher doses of 1,000-2,000 mg per day. It is effectively absorbed into the bloodstream and utilised by cells, efficiently boosting NAD+ levels with minimal side effects.

Effects on Cellular Health: By increasing NAD+ levels, NR supports many cellular processes. It is known to aid in DNA repair, maintain mitochondrial function, and support overall cell health. Higher NAD+ levels can also contribute to prolonged cell survival and better cellular function.

Energy Metabolism: With more NAD+, cells can convert nutrients into energy more effectively. This has a direct impact on overall vitality and energy levels, which can be particularly beneficial as we age or face metabolic diseases.

The Role of Nicotinamide Riboside in NAD+ Production

Nicotinamide riboside plays a crucial role in our quest to increase NAD+ levels. NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme in many biological processes, including metabolism and DNA repair.

As a precursor of NAD+, NR helps boost NAD+ levels more efficiently than other forms of vitamin B3. Studies highlight that NR can significantly elevate NAD+ concentrations in cells and tissues.

We frequently come across terms like niagen when discussing NR supplements. Niagen is a branded form of nicotinamide riboside known for its purity and effectiveness. Increasing NAD+ through NR can be a game-changer for those looking to support cellular health and longevity.

Researchers also explore different pathways that NR takes to convert into NAD+. NR utilises an independent route, bypassing some of the limitations encountered by other NAD+ precursors. This independent route enhances its potency in elevating NAD+ levels.

Enzymes like nicotinamide riboside kinase (NRK) are key players in this conversion process, as they facilitate the transformation of NR into NMN (nicotinamide mononucleotide) and subsequently into NAD+. Increased NAD+ levels can support better energy metabolism and cognitive function, making NR an attractive supplement.

Health Benefits of Nicotinamide Riboside for Cellular Health

Nicotinamide riboside plays a key role in maintaining cellular energy production and metabolic function. As a precursor to NAD+, NR helps elevate NAD+ levels within cells. Higher NAD+ levels are associated with improved DNA repair, enhancing the overall health of our cells.

NR has been found to aid middle-aged and older adults by boosting NAD+ levels and improving cellular energy metabolism which can slow down the effects of ageing and neurodegenerative diseases. The lipid-mobilising effects of NR are another benefit, promoting better fat metabolism and potentially reducing the risk of metabolic disorders.

Studies reveal that NR treatment can restore cognition and protect against cognitive decline. This suggests a potential role in preventing age-related cognitive impairments. Moreover, NR’s effects on blood NAD+ levels could translate into better vascular health and reduced risk of cardiovascular diseases.

NR also assists in reducing inflammation, a key factor in many chronic diseases. The increase in NAD+ leads to activation of sirtuins, proteins that play a pivotal role in cellular health and longevity. By supporting these mechanisms, NR offers substantial benefits for maintaining cellular health and overall well-being.

Comparing Nicotinamide Riboside with NMN and Other Vitamin B3 Supplements

When exploring the realm of Vitamin B3 supplements, we often encounter Nicotinamide Riboside and Nicotinamide Mononucleotide. Both compounds are noted for their potential to enhance NAD+ levels, vital for cellular function.

Nicotinamide Riboside (NR):

  • A synthetic form of Vitamin B3.
  • Direct precursor to NAD+.
  • Can cross cell membranes easily.

Nicotinamide Mononucleotide (NMN):

  • Must convert to NR before entering cells.
  • Essential for NAD+ synthesis.
  • Recently restricted in some markets.

Niacin and Nicotinamide (NAM):

  • Found naturally in food sources.
  • Less efficient at boosting NAD+ compared to NR and NMN.
  • Also known as nicotinic acid and niacinamide, respectively.

Metabolism: NR and NMN are metabolically linked. Once NMN enters cells, it converts to NR and then to NAD+. This intricate conversion underscores the importance of both compounds in NAD+ enhancement.


Here’s a brief look at their characteristics:




Market Availability




Widely available




Limited in some regions




Common in foods and supplements


We often use NR for its direct role in increasing NAD+ levels. NMN, while effective, undergoes additional steps to convert into NR, potentially influencing its efficiency.

Our understanding of these supplements can help us make an informed choice depending on specific health goals. Why choose NR, NMN, or other Vitamin B3 forms? This decision hinges on individual needs and accessibility.

Potential Side Effects of Nicotinamide Riboside and NR Supplements

When exploring supplements, it’s crucial to consider potential side effects, and nicotinamide riboside is no exception. Despite its benefits, like boosting NAD+ levels, there are some adverse effects to be aware of.

Most side effects of NR are mild. Common reactions include:

  • Nausea
  • Bloating
  • Skin issues such as itching and sweating

These effects aren’t severe and typically subside on their own.

Studies indicate that high doses (up to 2,000 mg per day) generally do not cause harmful effects. However, it is essential to consult with a healthcare professional before starting any new supplement, especially in higher doses.

In terms of regulatory approval, the Food and Drug Administration (FDA) has not issued specific guidelines for NR supplements. Therefore, we must rely on clinical trials and scientific studies to assess their safety.

For those considering NR, remember it’s important to monitor how you feel. If adverse effects like digestive issues or skin problems persist, reducing the dosage or discontinuing use and seeking medical advice can be prudent steps.

The Impact of Nicotinamide Riboside Chloride on Health

Acting as a potent NAD+ booster, it belongs to the vitamin B3 family. This compound enhances cellular energy by increasing levels of NAD+, an essential coenzyme involved in metabolic processes.

Studies show that nicotinamide riboside reduces the risk of neurodegenerative diseases by supporting DNA repair. It’s fascinating how nicotinamide from this source can have such wide-ranging effects. The compound also helps fight inflammation, which could lead to improved metabolic health.

Moreover, regular supplementation with nicotinamide riboside chloride has shown promise in extending the body’s lifespan. It potentially slows the ageing process by maintaining mitochondrial health. This makes it a compelling choice for those interested in longevity and overall wellness.

Combining nicotinamide riboside and pterostilbene can further amplify its effects. This powerful duo may significantly improve cognitive function and reduce oxidative stress. Many researchers believe that these discoveries of nicotinamide riboside open up new possibilities for treating chronic diseases.

Overall, the positive impact of nicotinamide riboside chloride on health is backed by science. It is considered safe for daily consumption, even at higher doses, as confirmed by various clinical trials. The extension of the use of nicotinamide riboside chloride into mainstream health regimes seems to hold great promise.

Including this supplement in our daily regimen might just be the edge we need to combat ageing and improve our health span. Have you considered how boosting your NAD+ levels could benefit your health journey?

Future Research and Developments in Nicotinamide Riboside and NAD+ Therapy

Nicotinamide riboside shows great promise as a supplement to raise NAD+ levels in the body. Current research is examining its effects on metabolic pathways and its role in enhancing health span.

Ongoing studies are focusing on the therapeutic uses of NR in a variety of conditions. Researchers are particularly interested in its potential to combat age-related illnesses through NAD+ elevation.

Clinical trials are key in this research. For instance, recent trials have shown that NR can be a potent booster of NAD+ levels. These trials will provide insight into the optimal dosage and long-term safety of NR supplements.

Phase I trials of nicotinamide riboside supplementation are crucial for understanding the appropriate amount of NR needed to achieve desired NAD+ levels without adverse effects.

Preclinical studies are also investigating NR kinase and its role in the Preiss-Handler independent route to NAD+ synthesis. Understanding this pathway could open new avenues for enhancing the effectiveness of NR.

Emerging research is evaluating the combination of NR with other NAD+ precursors like nicotinamide mononucleotide. This could provide a more comprehensive approach to NAD+ therapy by targeting multiple pathways in tandem.


In conclusion, nicotinamide riboside emerges as a powerful tool for enhancing cellular health and boosting energy levels, especially for healthy middle-aged and older adults. As a precursor, nicotinamide riboside increases NAD levels effectively, supporting various essential functions in the body. The administration of nicotinamide riboside is uniquely and orally bioavailable, making it a practical and efficient supplement choice.

Research has demonstrated that even a single dose of NR can lead to significant improvements in blood NAD levels, promoting better energy metabolism and overall vitality. The beneficial effects of NR extend to various aspects of health, including cognitive function, lipid metabolism, and cellular repair. For instance, nicotinamide riboside restores cognition and protects against age-related decline, making it a valuable supplement for long-term health.

Clinical trials of nicotinamide riboside have shown promising results, highlighting its safety and efficacy. The extension of the use of nicotinamide riboside as a nutrient underscores its potential to support healthy ageing. Furthermore, NR is not only converted to NAD+ but also works through independent pathways, such as the Preiss-Handler independent route to NAD, enhancing its effectiveness.

NR’s role in NAD metabolism is crucial, as it boosts NAD levels more efficiently than other forms of vitamin B3, like nicotinic acid riboside. This increase in NAD+ supports better energy production and cellular health, which are vital for maintaining overall well-being. The lipid-mobilizing effects of NR further contribute to its metabolic benefits, helping to manage weight and improve energy levels.

Current research and therapeutic uses of NR continue to expand, with studies exploring its impact on various health conditions. The combination of NR with other NAD precursors, such as NMN, offers a comprehensive approach to boosting NAD levels and supporting cellular function.

As we continue to learn more about the potential of nicotinamide riboside, it becomes clear that this supplement can play a significant role in promoting health and longevity. At Longevity Box, we are dedicated to providing high-quality, purity-guaranteed supplements that support your journey towards better health. Explore our range of products and discover how NR can enhance your life. Visit Longevity Box today to learn more and take the first step towards a healthier, more vibrant you.