NAD Reviews: Best NAD+ Supplement, NMN, Nicotinamide Riboside

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- Updated by Jody Mullis
Medically reviewed by Dr. Sidra Samad

Discover the top NAD+ supplements for longevity, age-related health, and cellular health. Read our in-depth reviews on NMN, boosters, and nicotinamide riboside.

NAD Reviews: Comprehensive Guide to Choosing the Right NAD+ Supplement


What makes NAD supplements a top pick for boosting health in 2024? Given the numerous NAD reviews praising their benefits, it’s clear why more people are turning to these supplements. Nicotinamide adenine dinucleotide (NAD) plays a crucial role in our cellular health, acting as a coenzyme involved in metabolic processes, energy production, and DNA repair. Unfortunately, NAD levels decline with age, impacting our overall well-being.

Recently, the biochemistry behind NAD has gained much attention. Researchers have discovered that taking NAD supplements can significantly increase NAD levels in the blood, thereby boosting energy and improving immunity. These supplements, especially when including doses of Nicotinamide Riboside (NR), effectively raise NAD levels, whether taken orally or through infusion, supporting your body’s natural functions and enhancing your quality of life.

We’ll explore the best NAD supplements available, from those that use high-quality ingredients to those offering a month’s supply. You’ll learn about the different forms, such as niacinamide and NMN, and how they compare in effectiveness. We’ll also touch on the importance of taking the recommended dose to get the best results, whether through a one-time purchase or a subscription.

Furthermore, we’ll discuss the test results and evidence supporting using NAD supplements. Whether you’re looking to boost NAD for increased collagen production, muscle tissue repair, or overall health, this guide will provide all the information you need. We’ll also highlight the importance of a trustworthy brand that guarantees the purity and effectiveness of its products.

At Longevity Box, we prioritise enhancing health and longevity with purity-guaranteed supplements, trusted by over 100,000 customers. Our products are meticulously third-party tested, ensuring they are free from fillers, binders, and preservatives. Discover the benefits of our scientifically-backed supplements, designed to support your well-being with the highest quality ingredients.

Interested in optimizing your health and energy levels? Explore our comprehensive guide on NAD supplements. We'll help you understand the benefits, compare top options, and choose the right supplement to enhance your well-being.

Understanding NAD+ and Its Importance for Cellular Health

Nicotinamide adenine dinucleotide (NAD+) plays a crucial role in our cellular health. As a central redox factor and enzymatic cofactor, NAD+ is essential for a wide range of cellular processes. It helps in metabolic pathways, DNA repair, and maintaining cellular homeostasis, contributing significantly to our overall health.

Levels of NAD+ naturally decline with age, which can lead to various age-related diseases. This decline impacts key cellular functions, resulting in compromised adaptive cellular stress responses. For instance, reduced NAD+ levels can impair DNA repair and neuronal plasticity affecting overall cellular resilience.

Boosting NAD+ levels has shown promising results in recent studies. Researchers have found that using NAD+ precursors can enhance cellular function and potentially slow the ageing process. These findings have sparked interest in the potential anti-ageing benefits of NAD+ supplementation.

NAD+ is also linked to energy homeostasis. Its involvement in metabolic pathways helps convert nutrients into cellular energy, which is vital for maintaining healthy cellular function. Some studies suggest that higher levels of NAD+ may aid in managing conditions like diabetes by improving metabolic efficiency.

Moreover, NAD+ plays a role in regulating cellular signalling pathways. It is involved in essential processes like calcium homeostasis, which affects cellular health and function.

There is also growing interest in the potential therapeutic applications of NAD+ modulation for diseases such as cancer, where cell metabolism and energy balance are crucial.

Given its broad impact, enhancing NAD+ levels through lifestyle changes or supplements might offer a viable strategy for improving health and longevity. Knowing the significance of NAD+ can lead us to explore practical ways to maintain its optimal levels, potentially enhancing our cellular health and overall well-being.


Comparing Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) for Longevity

Both Nicotinamide Riboside and Nicotinamide Mononucleotide are renowned for their potential to promote longevity. As our bodies age, the natural levels of NAD+ (nicotinamide adenine dinucleotide) decline, impacting various metabolic processes. NR and NMN supplements play vital roles as NAD+ precursors.

NR is converted into NAD+ through a two-step pathway. This makes it an efficient option for boosting NAD+ levels. On the other hand, NMN converts to NR before transforming back into NMN within cells. Research has revealed an elusive transporter that facilitates NMN’s direct transport into cells.

The efficacy of NR is supported by studies indicating its potential to raise NAD+ levels effectively. Furthermore, individuals may need to take a higher dose of NR to achieve noticeable health benefits. Like NR, NMN has shown promising results in raising NAD+ levels and improving age-related conditions. Both supplements appear to boost mitochondrial function, which is crucial for maintaining cellular energy and health.

A supplement such as NMN is often paired with resveratrol, another compound known for its anti-ageing properties. Together, they form a potent combination for enhancing longevity.





Conversion Pathway


Converts to NR then to NMN

Direct Transport


Yes, via Slc12a8 enzyme


Often requires a higher dose

Usually, lower doses are effective

Cellular Benefits

Boosts NAD+ levels and mitochondrial function

Raises NAD+ levels, improves metabolic functions



How NAD+ Supplements Can Boost Cognitive Function and Blood Sugar Levels

NAD+ supplements have shown promise in maintaining cognitive function, particularly in conditions like Alzheimer’s and vascular dementia. Increasing NAD+ levels in the brain enhances energy production by mitochondria, which may improve thought processes and alertness. This neuroprotective effect is crucial for both age-related cognitive decline and impairments caused by strokes or traumatic injuries.

Additionally, research indicates that NAD+ supplementation can have beneficial effects on blood sugar levels. By boosting NAD+ levels, the body can better regulate glucose metabolism, potentially aiding conditions such as diabetes. Better glucose control can also contribute to maintaining steady cognitive function, as glucose is a primary energy source for the brain.

A practical way to increase NAD+ naturally includes calorie restriction and fasting. These dietary strategies have been shown to elevate NAD+ levels, which, in turn, enhance the activity of SIRT1. SIRT1 is a protein that plays a significant role in cellular regulation and metabolism.

Another notable method involves supplements like Longevity Box’s Pure NR Nicotinamide Riboside, known for its high purity and bioavailability. This supplement provides a key building block for NAD+, essential for maintaining cellular health and longevity. Additionally, these supplements can provide an immediate boost to NAD+ levels, potentially aiding in both cognitive function and glucose regulation.

Interventions such as NAD+ drip therapy have demonstrated improvements in cognitive performance in healthy individuals. Although the exact mechanisms remain unclear, the overall improvement in mitochondrial function suggests a solid link to cognitive benefits.


Factors to Consider When Choosing the Best NAD+ Supplement: A Comprehensive Guide

Form of NAD+

NAD+ supplements come in various forms, including capsules, tablets, powders, and liquids. Each type has its own benefits. For example, powders and liquids can offer quicker absorption, whereas capsules are often more convenient.


To get the most from your NAD+ supplement, choose products that are free from binders, fillers, and preservatives. High-purity supplements ensure you receive the maximum benefits without unnecessary additives, supporting optimal cellular health and overall well-being."

Supplementation Format

Supplements like Longevity Box’s Pure NMN Powder are designed for high absorption and effectiveness. This product supports NAD+ levels efficiently, helping to boost cellular health and energy.

Per Serving Dosage

Check the dosage per serving. Some supplements, like Longevity Box’s Pure NR Nicotinamide Riboside, offer high potency in a single dose. Ensure that the dosage aligns with your health goals and daily requirements."

Cost and Value

Evaluate the cost-effectiveness of the supplement. Budget-friendly options like Longevity Box’s Pure Trans-Resveratrol Supplement offer high-quality NAD+ without breaking the bank. Additionally, consider the bundles offered by Longevity Box, which can provide a more economical per-dose cost, making them a great value for long-term use.

Absorption and Bioavailability

The form and additional ingredients can greatly affect absorption rates. Liposomal and sublingual forms are generally more bioavailable, ensuring that more of the active ingredient reaches your cells.

Money-Back Guarantee

Brands like Longevity Box offer a 60-day money-back guarantee, ensuring you can try their supplements with confidence. This commitment to quality and customer satisfaction reflects Longevity Box's dedication to providing purity-guaranteed supplements that support your health and longevity.

Combination with Other Supplements

Consider whether the NAD+ supplement can be combined with other supplements you are taking. Some formulations, such as those including Vitamin B3, integrate well with your current regimen.

Purpose of Taking NAD+

Different supplements might be better for specific goals. For instance, those aimed at anti-ageing might have a distinct formulation compared to those targeting athletic performance.

Brand Reputation

Research the reputation of the brand. Trusted brands provide transparent information about their sourcing, manufacturing processes, and third-party testing.


In this comprehensive guide to NAD+ supplements, we've explored various products and their benefits, ensuring you have all the information to make an informed choice. NAD+, which stands for nicotinamide adenine dinucleotide, is vital for cellular health, energy production, and overall well-being. With levels of NAD+ naturally declining as we age, finding the right supplement becomes crucial.

Over the past couple of years, the importance of maintaining optimal NAD+ levels has gained significant attention, especially in the context of anti-ageing and overall health improvement. Supplements like those offered by Longevity Box provide high-quality NAD+ boosters that can support your health goals effectively.

When selecting a supplement, consider factors such as dosage, purity, and the presence of any complementary ingredients like vitamin C or niacin, which can enhance the efficacy of NAD+ supplements. It's also essential to avoid products with fillers, binders, and preservatives, ensuring you get results without unnecessary additives.

For those looking for cost-effective options, Longevity Box’s Pure Trans-Resveratrol Supplement offers great value. Additionally, their bundles can provide an economical per-dose cost, making them a smart choice for long-term use.

It's worth noting that one form of NAD+ may not be inherently better than another; each serves unique functions within our cells. Therefore, consulting with healthcare professionals when considering several supplements can help avoid inefficiencies and ensure you achieve the desired results.

New drug developments and peer-reviewed studies continue to shed light on the potential of NAD+ supplements, but it's essential to approach these cautiously. Not all products are created equal, and the safest options often come from trusted sources that use only high-quality ingredients. Longevity Box, for instance, backs its products with a 60-day money-back guarantee, reflecting its commitment to customer satisfaction and product efficacy.

As we wrap up, remember that maintaining NAD+ levels is a step towards better health and longevity. By being informed and choosing the right supplements, you can support your cellular health and overall well-being. Always seek professional medical advice to tailor your approach to your specific health needs.

Take control of your health journey today by exploring our range of NAD+ supplements at Longevity Box. Discover more insightful articles and products designed to enhance your well-being and support your longevity goals.