How NMN Is Made

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- Updated by Max Way, Designation

how nmn is made

This article will explore the manufacturing process by which NMN is produced, both naturally in the body and also how it is manufactured for supplementation. It will consider the various stages of manufacturing required to produce this supplement, as well as discuss the potential health benefits associated with taking it. By examining these aspects, readers will gain a better understanding of how NMN is made and what advantages it may offer.

The production process for NMN involves several steps that ensure quality control and efficacy standards are met. It begins with the selection of raw materials such as proteins, enzymes, and other natural ingredients that have been scientifically proven to contain beneficial properties. These raw materials are then subjected to a series of processes such as blending, filtration, encapsulation, and packaging before being sent to retailers or consumers. Throughout these processes, manufacturers must adhere to strict guidelines set forth by regulatory bodies in order to maintain safety and efficacy standards.

Furthermore, research has suggested that NMN may possess numerous health benefits when taken on a regular basis. These include improved energy levels, faster metabolism rates, enhanced cognitive functions, better sleep quality, and reduced inflammation levels among others. Thus far, studies conducted on humans have been largely promising; however more research needs to be done before any definitive conclusions can be drawn regarding the long-term effects of taking NMN regularly.

Different Production Proceses In The Body

NMN, or nicotinamide mononucleotide, is a naturally occurring molecule in the human body. It plays an important role in cellular metabolism and many biochemical pathways. The primary method of producing NMN is through the conversion of nicotinic acid to icotinamide adenine dinucleotide (NAD). This process requires the presence of certain enzymes and cofactors in order for it to proceed efficiently.

In addition to this natural production, there are also supplements available that can boost levels of NMN in the body. These supplements are usually derived from yeast or bacteria, and they contain higher concentrations of NMN than what can be found naturally. While these supplements have been shown to have some benefits for health, caution should be taken when taking them as their long-term effects are still unknown.

Due to its importance in cellular metabolism and biochemical pathways, NMN has become a popular supplement among those looking to improve their health and wellness. As more research is conducted on its potential benefits and drawbacks, it's likely that interest in this molecule will continue to grow

Salvage Pathway

In addition to de novo synthesis, NMN can also be produced using a process known as the salvage pathway. This method involves the recycling of pre-existing molecules, such as icotinamide adenine dinucleotide (NAD+), into NMN. The NAD+ is broken down by enzymes such as nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide riboside kinase (NRK) before being converted into NMN. This process has been found to be effective in producing NMN for use in research and clinical studies.

The advantage of this technique is that it can produce large amounts of NMN quickly and efficiently with minimal resources. Additionally, it has been found to reduce cell death caused by oxidative stress, which could be beneficial in potential treatments involving NMN. Furthermore, the salvage pathway could potentially be used to increase the availability of NAD+ for use in metabolic pathways such as the electron transport chain.

Dietary Sources

In addition to the salvage pathway, NMN can also be obtained through dietary sources. It is found naturally in some foods such as broccoli, beef liver, and tuna, and can also be taken as a dietary supplement or oral NMN. Dietary supplements containing NMN are becoming increasingly popular due to their potential benefits in promoting cellular energy metabolism and providing protection against oxidative stress. NMN is often referred to as a “vitamin B” because of its ability to act as an energy source for cells.


As an alternative to obtaining NMN from dietary sources, individuals may also consider taking an NMN supplement. NMN is a precursor to the compound nicotinamide adenine dinucleotide (NAD+), which plays a key role in energy metabolism and other cellular processes. Supplementation with NMN has been shown to increase NAD+ levels in the body, leading to potential benefits such as improved energy levels, better mental clarity, and protection against age-related illnesses.

NMN can be found in both food and health products, including tablets, capsules, liquid drops, and powders. It is important to note that while taking an NMN supplement may have certain benefits, they should still be taken with caution. Studies suggest that long-term use of high doses of NMN may cause liver damage or negatively affect the immune system or cell membrane integrity. Therefore, it is important to consult with a healthcare professional before taking any supplement containing this compound.

Different Ways NMN Can Be Manufactured

NMN can be manufactured in a variety of ways, each with its own set of benefits and drawbacks. The most common method is the ad biosynthesis pathway mediated by two enzymes, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamidase (NMNAT). This enzymatic method is relatively simple and cost-effective, but the yields are often low.

Another method used to manufacture NMN is fermentation. This process involves introducing certain bacteria into an environment with high concentrations of NMN precursors, such as nicotinate or nicotinamide riboside. During the fermentation process, the bacteria will break down these precursors and produce NMN as a result. While this method produces higher yields than the enzymatic methods, it can also be more costly due to the need for specialized equipment.

Different Manufacturing Techniques

The manufacturing process of NMN is an essential step in the production of this longevity compound. Given its potential therapeutic value, manufacturers must ensure that their product is produced in a safe and effective manner. The most common technique used to manufacture NMN is chemical synthesis, which involves combining nicotinamide riboside or nicotinic acid with phosphorous pentoxide. This method produces high yields but is more expensive than other methods due to the need for specialized equipment and higher energy costs.

Fermentation is another manufacturing technique used to produce NMN. This process requires introducing certain bacteria into an environment with high concentrations of precursors such as nicotinate or nicotinamide riboside. During fermentation, these precursors are broken down by the bacteria resulting in the production of NMN. While this technique yields higher amounts compared to chemical synthesis, it can also be costly due to the need for specialized equipment and expertise.

Chemical Synthesis

Chemical synthesis is the most commonly used manufacturing technique for producing NMN. This method involves combining nicotinamide riboside or nicotinic acid with phosphorous pentoxide in a reaction that produces high yields. The resulting compound is then purified and tested for quality control before being sold as a nutritional supplement.

The production of NMN through chemical synthesis is beneficial because it does not require specialized equipment or expertise, making it a relatively inexpensive process. Additionally, the synthetic NMN produced this way is chemically identical to natural NMN and thus offers all of the same potential benefits.


In addition to chemical synthesis, NMN can also be manufactured through fermentation. This process involves the microbial conversion of organic compounds into NMN, making it a relatively cost-effective and eco-friendly method for producing the molecule. Furthermore, studies have shown that microbial fermentation of nicotinic acid or its derivatives can yield higher concentrations of NMN than chemical synthesis.
Overall, both chemical synthesis and fermentation are viable methods for producing NMN for nutritional supplements. Chemical synthesis is a cost-effective technique that produces high yields, while microbial fermentation offers an eco-friendly way to produce higher concentrations of NMN than chemical synthesis alone. 

Enzymatic Synthesis

Enzymatic synthesis is another method for producing NMN that has recently been explored. This process involves the conversion of the coenzyme nicotinamide adenine dinucleotide (NAD) into NMN by enzymatic processes. Studies have demonstrated that this technique can yield higher concentrations of NMN than chemical or fermentation-based synthesis, making it an attractive option for the production of dietary supplements.

Combination Of Methods

In addition to enzymatic synthesis, a combination of several methods may be used to produce NMN. For instance, although NAD is the most commonly used precursor for enzymatic synthesis, other starting materials such as nicotinamide riboside (NR) can also be employed. NR can be synthesized through chemical or fermentation-based processes and then converted into NMN by an enzymatic reaction. This method has been found to yield higher concentrations of NMN than enzymatic synthesis alone, making it an attractive option for producing dietary supplements.

Recent studies have also suggested that supplementing with NMN may help slow down age-associated physiological decline. For instance, research indicates that supplementing with this molecule may help improve cognitive function in individuals who are beginning to experience a decrease in their mental abilities due to aging. Furthermore, findings from animal studies suggest that supplementation with NMN may help protect against damage caused by oxidative stress and improve mitochondrial function in various mammalian cells, including brain cells.

Finally, evidence suggests that decreased production of NMN due to aging may contribute to the development of metabolic disorders such as type 2 diabetes. In fact, research has found that supplementing with this molecule can lead to improved insulin sensitivity and increased glucose uptake in human cells. These findings indicate that taking a daily dosage of NMN may be beneficial for individuals who are at risk for developing these types of metabolic disorders.


The production of NMN is a complex process that can be achieved through a variety of methods. De novo synthesis, salvage pathway, dietary sources, supplementation, chemical synthesis, fermentation, and enzymatic synthesis are all potential means for producing NMN. Each production method has its own advantages and drawbacks which must be taken into consideration in order to determine the most suitable option.

The combination of different production processes may also be necessary in order to meet the desired level of NMN production. For example, supplementing the body's natural de novo synthesis process with additional dietary sources or using fermentation in tandem with chemical synthesis could lead to greater efficiency and cost-effectiveness.

Overall, it is clear that there are many ways to produce NMN and each comes with its own set of benefits and drawbacks depending on an individual's needs. Careful consideration should be given when determining which method will provide the best results for a particular application. As research into this area continues to evolve, new developments may further refine our understanding of how NMN can be produced in an efficient manner.