David Sinclair’s Supplements - The Ultimate Stack

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- Updated by Jody Mullis MS, RD, Nutritionist

Key Takeaways

  • Dr. David Sinclair is one of the world leaders in longevity, giving health enthusiasts worldwide tools to combat illnesses and slow aging.
  • David’s supplement stack has been a hot topic in the health community for a long time and analyzing it may help us better understand how we can take our longevity game to a higher level.
  • Metformin is likely one of the essential supplements David takes, as well as NMN and resveratrol.
  • Looking at NMN, David said the supplement’s effects on the body are astounding, causing NAD+ levels to rise, mimicking fasting or considerable exercise.
  • On top of supplements, David also suggests a healthy routine involving a nutritious diet, exercising regularly, and having his blood work done every few months.


David Sinclair’s Supplements Ultimate Stack: Have a Healthy Body With His Regimen

Teaching at the Harvard Medical School for over 16 years, Dr. David Sinclair is a world-leading expert when it comes to aging, why we age, and the genetics that underpins the aging process.

His research has paved the way for cutting-edge bio-hacks on epigenetic reverse aging, and how certain enzymes react to different levels of NAD+, giving the public ways to fight against illnesses and cancer, among other aging ailments.

David Sinclair is also the author of “Lifespan: Why We Age – And Why We Don’t Have To,” a best-seller that talks about longevity, how we can expand our lifespans, and the proven research behind each method.

What Supplements Does David Sinclair Take?

David Sinclair has made a point to refrain from recommending any supplement, instead suggesting to his readers to look for supplements from reputable companies with a high pure molecule percentage.

However, David has shared from his books and other public sources what he takes, and we’ve made a list that compiles all of this information. Unfortunately, as this isn’t directly from David, we cannot be certain whether his regimen has changed or if he takes additional supplements beyond this list.

As an example, David has mentioned in “Lifespan” that NMN and resveratrol are on his list of daily morning supplements, which he takes with yogurt.

We’ve compiled a list based on how often David mentions the supplements he takes, thus implying how important each supplement is to him and his regimen. This list includes information David has provided from interviews, books, and other public sources.

David Sinclair Supplements List

Dr. David Sinclair’s daily supplement stack, taken from various sources and have ranked them based on our view of their importance and efficacy in the Longevity space:

    1. Metformin: Taken in the evening, at around 800 mg
    2. NMN: Taken in the morning, at 1g
    3. Resveratrol: Taken in the morning as well, at 1g 
    4. Quercetin and Fisetin: Taken in the morning, at roughly 500 mg for each
    5. Spermidine: Taken in the morning at roughly 1 mg
    6. Trimethylglycine: Taken daily at roughly 500 to 1000 mg
    7. Vitamin D3: Taken daily, at around 4000 to 5000 IU
    8. Vitamin K2: Taken daily at around 180 to 360 mg
    9. Alpha-lipoic Acid: Amount taken currently unknown
    10. Coenzyme Q10: Amount taken currently unknown
    11. Low-dose Aspirin: Taken daily at roughly 83 mg
  • Statins: Taken daily at roughly 80 mg

  • Metformin

    According to David, the proven benefits of metformin are surprising and numerous. Going on to mention several studies in his book, “Lifespan,” David noted that Metformin was “particularly promising,” giving hope to longevity enthusiasts worldwide.

    Metformin, when given to diabetic patients, garnered results that could be applied to combating diseases, while also affecting the aging process. David also mentioned research where patients taking metformin had lower mortality rates compared to both diabetic and non-diabetic patients, along with an overall less amount of cardiovascular disease and cancer. No other anti-diabetic drug could produce similar results.

    Metformin, however, does have some side effects for some people, including diarrhea and abdominal discomfort when first introduced into the diet. After a few months, metformin has been known in some cases to reduce the body’s ability to absorb vitamin B12.

    Metformin is so effective because it causes our cells to repair and protect themselves due to the slight amount of damage metformin causes to the cells, specifically as a mitochondrial inhibitor.

    Due to this, David Sinclair never takes metformin on the days he exercises, as exercise creates a similar effect on the body’s cells, which could potentially put too much stress on the body if both are done at the same time.

    Metformin is also not recommended for those who are beyond a certain age threshold, such as being over the age of 65. This is because metformin could potentially cause too much stress on already aged cells.

    Dr. David Sinclair also mentions that the timing of metformin is incredibly important, as metformin can enhance the fasting state of the body. Our bodies automatically go into a fasting state while we sleep, so David takes metformin typically before bedtime at around 800 mg, once a day.

    This short clip provides an overview of Dr David Sincalir’s views on Metformin.

    Whilst Metformin is a very promising life-extension option, it is currently a medicine and therefore only available on prescription. Fortunately, there are natural molecules that have been found to have similar effects on the body and are not classified as a medicine. We’ve brought these potent molecules together in our new formula - Met4Min - +which brings 4 synergistic compounds to support METabolic optimisation and to MINimise insulin resistance, much like Metformin. 


    Research suggests that NMN can affect many aspects of age-related diseases. One study found that mice that were given NMN had their NAD+ levels increase, leading to a decline in physiological diseases.

    David himself found the data promising, quoting in “Lifespan” that if a test subject was given anything with NMN in it, their NAD+ levels would rise by at least 25%, the equivalent of having fasted or exercised a considerable amount.

    Pure NMN is imperative to the human body; It’s a molecule that enables proteins to properly function with a variety of jobs, such as repairing DNA and the epigenome.

    With 1000 mg being on the higher dosage amount, 250 or 500 mg is also a fair dosage amount to reap the benefits of NMN. This particular study showed promising results with just 250 mg daily.

    On page 150 of David’s book, he comments that many people ask him which is better, NMN or NR?  He goes on to say that his research suggests that NMN is the preferable choice out of the two, as certain health benefits aren’t seen in NR as they are in NMN when used in studies. However, NR has still proven to expand life, and while NMN is still undergoing testing, David isn’t able to give a definitive answer yet.

    Dr Sinclair speaks often about NMN. This clip is our favorite as he concisely summarises the benefits.


    NMN is our flagship product and can be found here.


    David mentions in “Lifespan” that resveratrol, a stilbenoid acquired from grape skins, seems like a suitable candidate for cancer and cardiovascular disease prevention. Resveratrol is proven to have the ability to affect tumors, which can be related to other diseases with similar expressions in the body.

    Not only is resveratrol effective on its own, but David also believes that resveratrol’s full potential is unlocked with the help of NMN. This potential is found in two parts: activating the sirtuin genes (the protectors of the body’s DNA and epigenome) with resveratrol, while giving the genes energy with NMN.

    Dr Sinclair was central to the team that discovered the benefits of Resveratrol. In the clip he talks about the positive impacts it has on health and longevity.