Healthy ageing isn’t about chasing immortality, it’s about optimising resilience. The right longevity stack combines evidence-based compounds that help maintain cellular function as we age.
Studies such as one from Nature Aging in 2025 (see research) show that targeted nutritional combinations, polyphenols, omega-3s, and B-vitamins may protect mitochondria, enhance DNA repair, and modulate inflammation.
At Longevity Box, we translate this science into practical stacks, clean formulations, third-party tested, and easy to integrate into daily life.
Core Stack: Urolithin A + Magnesium + TMG
This trio forms the backbone of a pragmatic longevity stack. Each plays a unique role in cellular energy and mitochondrial health.
Morning/Evening Protocol Templates
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Morning: Start with MitoSurge Urolithin A 500 mg. Taken with water before breakfast, Urolithin A supports mitophagy, the body’s natural recycling of old mitochondria, and a process difficult to trigger consistently through diet alone
A 2025 review in ScienceDirect found that nutrients such as Urolithin A and polyphenols may enhance mitochondrial biogenesis and improve energy metabolism by activating signalling pathways like PGC-1α and Sirt1. -
Midday: Add TMG Supplement. This methyl donor helps regulate homocysteine and supports DNA methylation, which is essential for maintaining energy and cognitive clarity.
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Evening: Include a bioavailable magnesium. A UK pilot study found that circulating ionised magnesium is the best marker of supplement bioavailability, confirming that complex formulations help sustain mitochondrial enzymes involved in ATP production and protein synthesis.
Budget Tiers (Prioritisation)
If you’re building from scratch:
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Start with Urolithin A. It directly supports mitochondrial renewal.
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Add Magnesium. It’s a cofactor in over 300 enzymes linked to energy production and metabolism.
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Layer in TMG. It complements NAD⁺ precursors and maintains methylation balance, vital for longevity pathways.
Together, this stack includes the essentials for sustaining cellular vitality and protecting the body’s powerhouse organelles, the mitochondria.
When to Add NAD⁺ Boosters (NMNH & Nicotinamide Mononucleotide)
The next step in most longevity stacks is NAD⁺ support. NAD⁺ levels decline with age, reducing the efficiency of mitochondrial function and DNA repair.
Adding Pure NMNH, a precursor to NAD, can help restore balance. Researchers such as David Sinclair have long discussed how NAD⁺ precursors fuel sirtuin pathways, which regulate cellular metabolism and stress response.
A 2024 summary from NutritionDiets.co.uk noted that combining CoQ10, L-carnitine, NAD⁺ precursors, and magnesium synergistically boosts mitochondrial energy output while reducing oxidative stress.
When adding NAD⁺ boosters:
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Start slow, allow two weeks for adjustment.
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Pair with TMG to maintain methylation.
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Cycle every 8–10 weeks to avoid adaptation.
Think of NMNH as fuel for the signalling pathways that regulate mitochondrial and metabolic performance, a smart extension of your foundation stack.
Cycling and Phases: When to Rest or Rotate Supplements
Long-term success with supplementation comes from rhythm. The body adapts; cycling helps sustain responsiveness.
A simple approach:
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Active Phase (8–12 weeks): Follow your full stack, Urolithin A + TMG + Magnesium + NMNH.
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Rest Phase (2–4 weeks): Keep only magnesium; allow NAD⁺ and methylation cycles to reset.
During the Rest Phase, focus on lifestyle habits that naturally activate the same pathways: intermittent fasting, hydration, and low-intensity exercise to trigger autophagy.
According to WMS Press Media, nutrients such as B-complex vitamins, creatine, and alpha-lipoic acid can also sustain cellular energy production during off-cycles, maintaining stability in older adults.
The key isn’t perfection; it’s consistency. Periodic rotation avoids deficiency and keeps your cells responsive.
Supporting Compounds: Quercetin, Spermidine, and Omega-3
Every longevity stack benefits from supportive antioxidants and anti-inflammatory compounds.
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Quercetin, a flavonoid polyphenol, may act as a mild senolytic, helping clear worn-out cells and reduce low-grade inflammation.
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Spermidine, discussed in Nature Aging (2025), activates autophagy, clearing damaged proteins and sustaining mitochondrial health.
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Omega-3 fatty acids protect mitochondrial membranes from oxidative stress while improving protein synthesis and energy production efficiency.
A 2025 review on ScienceDirect found that omega-3s and polyphenols enhance mitochondrial resilience by upregulating PGC-1α and Sirt1, improving energy metabolism and overall energy balance.
These supporting nutrients act like background maintenance, quietly protecting your cells while the core stack drives regeneration.
Transparency and Third-Party Testing
A smart longevity supplement strategy isn’t just about what you take, it’s about what you can trust. Transparency matters.
Every product in the Longevity Box range, from MitoSurge Urolithin A to Pure NMNH and TMG, is independently verified for purity and potency. Each batch is third-party tested and backed by a 700-day purity guarantee, rare transparency in an industry crowded with filler-based formulations.
When building your stack, check for:
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Independent lab verification (not in-house claims).
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Clear disclosure of excipients.
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Stability data ensuring purity beyond the expiry date.
Our approach is simple: honesty, consistency, and results you can feel. You’ll never find binders, artificial colours, or unlisted ingredients in our formulations, only nutrients selected for their role in maintaining health and longevity.
Key Points to Remember
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A longevity stack combines nutrients that support cellular energy, DNA maintenance, and mitochondrial function.
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The core stack of Urolithin A + TMG + Magnesium supports energy production and metabolic balance.
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Adding NMNH or nicotinamide mononucleotide restores declining NAD⁺ and may help sustain mitochondrial efficiency.
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Compounds like quercetin, spermidine, and omega-3 enhance resilience by promoting autophagy and reducing oxidative stress.
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Transparency matters: choose third-party tested supplements free from fillers and additives.
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Healthy ageing is about consistent support, not quick fixes. Build intentionally, stay consistent, and age with vitality.
Conclusion: Build Your Stack for Healthy Ageing
True longevity isn’t about more candles on the cake, it’s about the strength to blow them out with ease.
By curating a supplement stack rooted in research and transparency, you support the core of healthy ageing: efficient mitochondria, steady energy levels, and resilient cells.
At Longevity Box, we’ve built our philosophy around this evidence-led simplicity. The core stack, Urolithin A, TMG, and Magnesium, forms your foundation. Add NMNH to restore levels of NAD, and use antioxidants like Quercetin, Spermidine, and Omega-3 to round it out.
Build your stack today at Longevity Box, because healthy ageing starts at the cellular level.