• 10mg active Spermidine per serving
• Independently lab tested
• 100% natural and non-GMO
• No fillers, vegan and allergy friendly
• 120 x 250mg capsules

Millions of cells in your body die every second, and as we age, the body’s ability to replace these cells quickly diminishes. 

As we grow older, the body's ability to activate the process of autophagy slows down in the body. Repaired cells are similar to young cells, and perform even better. The process of autophagy replaces old and damaged cells with healthier newer versions. 

What is Spermidine and Why is it Essential?

Spermidine is a naturally occurring polyamine found in all living cells. It plays a crucial role in cellular processes, including autophagy, a process that aids in cellular renewal by recycling damaged components. The potential benefits of spermidine are profound as it promotes better cell renewal, supporting overall healthspan and vitality. With age, spermidine levels tend to decline, making supplementation an exciting strategy to counteract the root causes of aging.

How Does a Spermidine Supplement Work?

Our spermidine supplement amplifies the natural benefits of spermidine by enhancing autophagy. This process, known as what's called autophagy, helps the body efficiently remove damaged cellular components, thereby promoting cell renewal and rejuvenation. When you think about spermidine, consider its ability to support cognition and heart health, enhance energy levels, and facilitate improved gut health.

What Are the Health Benefits of Spermidine?

The health benefits of spermidine are diverse and significant. Spermidine supplementation has been linked to supporting healthy aging by boosting the body's natural ability to produce essential components for cellular health. Additionally, many notice faster growing hair and nails due to improved cellular rejuvenation processes. Enhanced brain health, better gut health, and increased collagen synthesis are also some of the noticeable benefits users experience.

How is Autophagy Linked to Longevity?

Autophagy plays a pivotal role in longevity by enabling the body to recycle and dispose of cellular waste, a process crucial for maintaining and enhancing healthspan. By encouraging your own body's natural ability to perform autophagy, our spermidine supplement aids in delaying the aging process. This contributes to a more prolonged and healthier life, embodying the essence of a longevity supplement.

How Does Wheat Germ Factor In?

Wheat germ is a powerful source of natural spermidine. Including it in our spermidine supplement ensures a rich, natural source of this polyamine, which is essential in supporting cellular functions and longevity. By choosing food-derived spermidine, we harness nature's own method for fostering health and vitality, avoiding the need to use synthetic spermidine.

Why Choose Our Spermidine Supplement?

Selecting the right supplement means choosing one that prioritises quality ingredients and rigorous quality control and third party testing. Every batch of our spermidine supplement is independently tested for safety and efficacy, ensuring each dose is reliable. By using natural spermidine sourced from wheat germ and developed in an FDA CGMP facility, we guarantee an exceptional quality spermidine product that meets the highest standards.

Our spermidine is also free of additives, fillers, binders or preservatives. You will find nothing but active ingredients in every single Longevity Box supplement.

Our world-leading 700-day purity guarantee 

Our 700-day purity guarantee ensures that our products remain pure and reliable form the moment they arrive until you finish taking them. Peace of mind that you truly are extending your healthspan.

What Makes Our Supplement Suitable for Vegans?

Our supplements are crafted with quality ingredients and adhere to a strict supplement manufacturing process that avoids animal derivatives, making them suitable for vegans. We prioritize the use of plant-derived sources ensuring the purity and integrity of every ingredient, standing apart with our commitment to ethical and sustainable practices.

Human clinical trials of Spermidine

Dietary polyamine intake lowers the risk of all-cause and cardiovascular disease-related mortality

Jieun Kim , Younghwa Baek, Siwoo Lee

Journal of Functional Foods

Spermidine Supplementation and Cognitive Function in Older Adults

Wirth, M., Benson, G., Schwarz, C.

Frontiers in Aging Neuroscience, 2020.

The Effect of Spermidine Supplementation on Cognitive Function in Adults: A Mini-Review

Principles and Practice of Clinical Research, 2023

Impact of Spermidine-Rich Diet on Healthspan: A Clinical Trial

Eisenberg, T., Abdellatif, M., Schroeder, S.

Nature Medicine, 2019.

Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline

Claudia Schwarz, Gloria S Benson, Nora Horn, Katharina Wurdack

JAMA Network Open, 2022.

Spermidine FAQ

Is Spermidine As A Supplement Safe?

Spermidine is safe as a supplement as it is one of the naturally occurring compounds in our body. 

According to several clinical trials and scientific studies, it is entirely safe as a dietary supplement for healthy adults without having any side effects. 

When Should You Take Spermidine Supplements?

Based on your preference, you should take spermidine supplements after any meal of the day, may it be after breakfast, lunch, or even in the evening. However, it is recommended to always take your supplement consistently at the same time during the day.

Why Should You Take Spermidine With Food?

One-third of spermidine is naturally produced by the cells in our body, and the rest is taken and absorbed through certain bacteria present in your digestive tract.

Therefore, a diet balanced with a high amount of rich nutrients and spermidine sources keeps the level high.

What Foods Are High In Spermidine?

High levels of Spermidine is found in many vegetables such as potatoes, cauliflower, legumes, chickpeas (garbanzo beans), broccoli, fresh green pepper, lentils, wheat germs, rice, and rice bran. According to an estimate, people derive about 30% of all spermidine from wheat and whole grains.

Spermidine is also present in high concentrations in some fruits, such as mango. Other foods, including cheeses, amaranth grain, durian, miso, fermented soybean, or tofu (also known as natto), have high spermidine content. 

Mushrooms such as maitake mushrooms, oyster mushrooms, and snow mushrooms are also rich in spermidine.

How Quickly Does Spermidine Work?

Customer feedback and anecdotal reports show that spermidine supplements can take up to 90 days to see beneficial changes in the body if taken at 10mg per day. Natural supplements take time to adjust with your body, as with any supplement or regimen.

Where is the Best Place to Find Information on Spermidine?

Before taking spermidine supplements or changing your diet, you should consult with your doctor and do detailed research on spermidine and its impacts on your body. 

There are many studies and documentaries showcasing the effects of spermidine, which can help you take a healthy step in adding these longevity-increasing spermidine intake in your diet.

Who Should Not Take Spermidine Supplements?

Spermidine supplements are not recommended during pregnancy and lactation. According to health experts, it is not safe to take a spermidine supplement if you are pregnant or a nursing mother. It is also not suitable for children, as they are not in need of supplements such as spermidine. 

From What Age Should You Start Taking Spermidine Supplementation?

You can start taking spermidine supplements in your twenties and onwards. Although the natural autophagy process is working at its best during the early twenties, you can still begin to take spermidine supplements as it will only enhance autophagy with no side effects on your metabolism.

How Should I Feel After Taking Spermidine Supplements?

After four weeks of regular spermidine supplementation, you should feel the same as you would feel during regular fasting for a few days.