- Over 99% pure
- Independently lab tested
- No additives, binders or fillers
- Gluten-free, vegan and allergy friendly
About Resveratrol Supplements:
Resveratrol is a naturally occurring compound and is a polyphenol which is present in a number of common food items such as berries, grapes, vine, peanuts, etc. Plants that produce resveratrol do so partly as a protective mechanism and response to stressors within their environments, including the presence of insects or other predators, damage, injury, and fungal varieties. Resveratrol is believed to be one of the most potent polyphenols.
The properties of resveratrol were first discovered when researchers established that a variety of yeasts, microbes, insects and animals that were fed resveratrol experienced an increased lifespan. Several studies continued to confirm these properties in their successful work on flies, fish, mice and nematode worms, all of which lived longer compared to control groups that were not treated with this phytonutrient.
How Does Resveratrol Supplement Work?
Resveratrol supplements can either passively cross cell membranes or interact with its receptors due to its unique physical and chemical properties, making it possible for Resveratrol to interact with inter and extracellular molecules effortlessly. It is because of this that its mechanism of action is triggered by one of the two means (at a cellular level):
- By developing its effect inside the nucleus
- Activating intracellular mechanism by first activating signalled pathways when binding to receptors of the cell membrane
The way it potentially functions as an longevity-promoting substance can possibly be explained how it activates SIRT. A study suggests that it can directly activate NMNAT enzyme which increases the intracellular activity and levels of NAD+ which is likely to affect SIRT which primarily requires the presence of NAD+ in order to function. In another experiment, human cells were treated with Resveratrol independent of NMNAT enzyme. Even without the presence of NMNAT, Resveratrol still rejuvenated old cells which started to divide and develop longer telomeres with the restoration of the splicing factor expression. The cells not only started to appear younger but behaved more like younger cells as well.
Dosage and Guidelines:
It is advised to begin taking Resveratrol with a low dose to determine whether the product suits you or if your body is reacting against it (it is highly unlikely and no such cases have been recorded). The first dose should not exceed more than 125mg (taken as per the directions indicated on the packaging) and then monitor for possible adverse side-effects or reactions which are very unlikely and have never been observed.
Directions for Regular Use:
There are multiple research papers into the optimum method of absorption of Resveratrol supplement UK and no current consensus on the best way to take it. Amongst the various papers, it has been observed that Resveratrol’s bioavailability can be improved when consumed with a food that has an element of fat content. This observation is complementary to Dr David Sinclair’s approach which is to take Resveratrol with yoghurt at breakfast. This paper explores the various studies on intake options. Other studies, also included in the aforementioned paper, have indicated taking Resveratrol with green tea will enhance its effects and is best taken on an empty stomach.
Recommended Daily Dosage:
2 capsules (1 gram) per day.
Upper Dosage (Depending upon the age and other factors):
2 grams per day.
If you are on prescribed medication or have been medicating for a long term previously, then it is best to consult with your doctor before starting with Resveratrol.
References and Further Readings:
For the convenience of the customers and enthusiasts, listed below are several links for references. Please keep in mind that none of the sources listed below is affiliated with Longevity Box in any way, nor did they use our Pure Resveratrol Supplements UK in their studies. For video resources, you can watch this video (duration 57 minutes). Other resources include:
Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., Zipkin, R.E., Chung, P., Kisielewski, A., Zhang, L.L. and Scherer, B., 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature, 425(6954), pp.191-196.
Siemann, E.H. and Creasy, L.L., 1992. Concentration of the phytoalexin resveratrol in wine. American Journal of Enology and Viticulture, 43(1), pp.49-52.
Podcast Notes. 2021. The Joe Rogan Experience - David Sinclair, Ph.D. • Podcast Notes. [online] Available at: <https://podcastnotes.org/joe-rogan-experience/sinclair/> [Accessed 1 February 2021].
Blanchard, O.L., Friesenhahn, G., Javors, M.A. and Smoliga, J.M., 2014. Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept. PloS one, 9(2), p.e90131.
En.wikipedia.org. 2021. Sublingual administration. [online] Available at: <https://en.wikipedia.org/wiki/Sublingual_administration> [Accessed 1 February 2021].
Stockinger, J., Maxwell, N., Shapiro, D., deCabo, R. and Valdez, G., 2018. Caloric restriction mimetics slow aging of neuromuscular synapses and muscle fibers. The Journals of Gerontology: Series A, 73(1), pp.21-28.
Timmers, S., Konings, E., Bilet, L., Houtkooper, R.H., van de Weijer, T., Goossens, G.H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S. and Moonen-Kornips, E., 2011. Calorie restriction-like effects of 30 days of resveratrol UK supplementation on energy metabolism and metabolic profile in obese humans. Cell metabolism, 14(5), pp.612-622.
- It is advised to use this product at your own discretion. Resveratrol mass-production started in 2000 and long-term effects on humans are yet to be determined.
- This is just a supplement and should not be considered as an alternative for a varied diet.
- Consult with your doctor before incorporating it into your daily routine.
- In the test-tube analysis, Resveratrol has been found to inhibit platelet aggregation; higher intake with blood thinners and anticoagulants may cause bruising or bleeding.
- Research around Resveratrol is still ongoing and as more is discovered about Resveratrol, the content on the website may get updated or changed altogether.